The crystal structure of donepezil hydrochloride, form III, has been solved with FOX using laboratory powder diffraction data previously submitted to and published in the Powder Diffraction File. Rietveld refinement with GSAS yielded monoclinic lattice parameters of a = 14.3662(9) Å, b = 11.8384(6) Å, c = 13.5572(7) Å, and β = 107.7560(26)° (C24H30ClNO3, Z = 4, space group P21/c). The Rietveld-refined structure was compared to a density functional theory (DFT)-optimized structure, and the structures exhibit excellent agreement. Layers of donepezil molecules parallel to the (101) planes are maintained by columns of chloride anions along the b-axis, where each chloride anion hydrogen bonds to three donepezil molecules each.

中文翻译：

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盐酸多奈哌齐晶型 III，C24H29NO3·HCl 的晶体结构

盐酸多奈哌齐晶型 III 的晶体结构已通过 FOX 使用先前提交并发表在粉末衍射文件中的实验室粉末衍射数据求解。使用 GSAS 进行 Rietveld 细化得到单斜晶格参数一种= 14.3662(9) 埃，b= 11.8384(6) 埃，C= 13.5572(7) Å，和β= 107.7560(26)° (C24H30一氧化二氯3,Z= 4，空间群磷21/C）。将 Rietveld 改进的结构与密度泛函理论 (DFT) 优化的结构进行比较，结果显示出极好的一致性。平行于（101）平面的多奈哌齐分子层由沿b-轴，其中每个氯阴离子氢键到三个多奈哌齐分子。