Tris (2-chloroethyl) phosphate (TCEP) is an emerging aquatic environmental pollutant. In the present study, juvenile yellow catfish (Pelteobagrus fulvidraco) were exposed to environmentally relevant concentrations of TCEP for 30 days. The results showed that TCEP exposure decreased the survival rate (100 μg/L), body weight (10 and 100 μg/L) and specific growth rate (10 and 100 μg/L) of juvenile yellow catfish. Exposure to TCEP resulted in pronounced damages of gill structures. Gene transcription analysis showed that the antioxidant capacity of the liver and gills was affected; CYP1A1 might contribute to phase I metabolism of TCEP in the liver rather than CYP1B1; TCEP stress might increase the demand of ion transport in fish gill; TCEP could stimulate the immune response and might induce apoptosis via a p53-Bax pathway and caspase-dependent pathway in gills. Collectively, these findings provide new insights into the toxic effects of TCEP on fish.

三（2-氯乙基）磷酸酯（TCEP）是一种新兴的水生环境污染物。在本研究中，幼年黄鲶（Pelteobagrus fulvidraco）暴露于环境相关浓度的 TCEP 30 天。结果表明，TCEP暴露降低了黄鲇幼鱼的存活率（100 μg/L）、体重（10和100 μg/L）和比生长率（10和100 μg/L）。暴露于 TCEP 导致鳃结构明显损坏。基因转录分析显示肝脏和鳃的抗氧化能力受到影响；CYP1A1可能有助于肝脏中 TCEP 的 I 期代谢，而不是CYP1B1; TCEP胁迫可能增加鱼鳃对离子转运的需求；TCEP 可以刺激免疫反应，并可能通过鳃中的 p53-Bax 途径和半胱天冬酶依赖性途径诱导细胞凋亡。总的来说，这些发现为 TCEP 对鱼类的毒性作用提供了新的见解。