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Preparation and properties of bifunctional Gd2O3/GQD composite nanoparticles
Journal of Rare Earths ( IF 5.2 ) Pub Date : 2021-07-06 , DOI: 10.1016/j.jre.2021.06.010
Chengjie Xu 1, 2 , Meigui Ou 1, 2 , Hao Zhou 1, 2 , Chunlin Yang 3
Affiliation  

Nanocomposites of graphene quantum dots (GQDs) modified gadolinium oxide (Gd2O3) particles were successfully synthesized. In addition, the effects of the amount of GQDs and the particle size of Gd2O3 on the properties of nanocomposites were investigated. The structures and properties of nanoparticles were characterized by X-ray diffraction, X-ray photoelectron spectroscopy, Fourier transform infrared spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, photoluminescence spectrometry, and magnetic resonance imaging. The results show that the synthesized particles Gd2O3/GQD are spherical with a diameter of approximately 40 nm and have excellent fluorescence and magnetic property, and its relaxation rate (r1 = 25.18 (mmol/L)−1/s) is higher than that of the typical commercial contrast agents Gd-DTPA (r1 = 4.5 (mmol/L)−1/s). The fluorescence property of Gd2O3/GQD is optimized by varying the VGQDs:VGd2O3 ratio, and 1:1 ratio of VGQDs:VGd2O3 results in the best fluorescence property. The large particles of Gd2O3 improve the relaxation property of nanocomposites. Therefore, the nanocomposites Gd2O3/GQD with magnetic and fluorescence characteristics can be used in biological imaging, drug targeting, and in-vivo diagnostic analysis.



中文翻译:

双功能Gd2O3/GQD复合纳米粒子的制备及性能

成功合成了石墨烯量子点(GQDs)改性氧化钆(Gd 2 O 3 )粒子的纳米复合材料。此外,研究了GQDs的量和Gd 2 O 3的粒径对纳米复合材料性能的影响。通过X射线衍射、X射线光电子能谱、傅里叶变换红外光谱、场发射扫描电子显微镜、透射电子显微镜、光致发光光谱和磁共振成像对纳米粒子的结构和性质进行了表征。结果表明,合成的颗粒Gd 2 O 3/GQD呈球形,直径约40 nm,具有优异的荧光和磁性,其弛豫率(r 1  = 25.18 (mmol/L) -1 /s)高于典型的市售造影剂Gd- DTPA ( r 1  = 4.5 (mmol/L) -1 /s)。Gd 2 O 3 /GQD的荧光特性通过改变V GQDs : V Gd 2 O 3的比例和1:1的V GQDs : V Gd 2 O 3比例来优化产生最好的荧光特性。Gd 2 O 3的大颗粒改善了纳米复合材料的弛豫性能。因此,具有磁性和荧光特性的纳米复合材料Gd 2 O 3 /GQD可用于生物成像、药物靶向和体内诊断分析。

更新日期:2021-07-06
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