Nuclear factor κB (NF-κB) is a ubiquitous regulator of the signalome and is indispensable for various biological cell functions. NF-κB consists of five transcription factors that execute both cytoplasmic and nuclear signaling processes in cells. NF-κB is the only signaling molecule that governs both pro- and anti-apoptotic, and pro- and anti-inflammatory responses. This is due to the canonical and non-canonical components of the NF-κB signaling pathway. Together, these pathways orchestrate cancer-related inflammation, hyperplasia, neoplasia, and metastasis. Non-canonical NF-κB pathways are particularly involved in the chemoresistance of cancer cells. In view of its pivotal role in cancer progression, NF-κB represents a potentially significant therapeutic target for modifying tumor cell behavior. Several phytochemicals are known to modulate NF-κB pathways through the stabilization of its inhibitor, IκB, by inhibiting phosphorylation and ubiquitination thereof. Several natural pharmacophores are known to inhibit the nuclear translocation of NF-κB and associated pro-inflammatory responses and cell survival pathways. In view of this and the high degree of specificity exhibited by various phytochemicals for the NF-κB component, we herein present an in-depth overview of these phytochemicals and discuss their mode of interaction with the NF-κB signaling pathways for controlling the fate of tumor cells for cancer-directed interventions.

核因子 κB (NF-κB) 是信号组的普遍调节因子，对于各种生物细胞功能是必不可少的。NF-κB 由五种转录因子组成，它们在细胞中执行细胞质和核信号传导过程。NF-κB 是唯一控制促凋亡和抗凋亡以及促炎和抗炎反应的信号分子。这是由于 NF-κB 信号通路的规范和非规范成分。这些途径共同协调与癌症相关的炎症、增生、瘤形成和转移。非经典 NF-κB 通路特别涉及癌细胞的化学抗性。鉴于其在癌症进展中的关键作用，NF-κB 代表了改变肿瘤细胞行为的潜在重要治疗靶点。已知几种植物化学物质通过抑制其磷酸化和泛素化来稳定其抑制剂 IκB 来调节 NF-κB 途径。已知几种天然药效团可抑制 NF-κB 的核转位以及相关的促炎反应和细胞存活途径。鉴于这一点以及各种植物化学物质对 NF-κB 成分表现出的高度特异性，我们在此深入概述了这些植物化学物质，并讨论了它们与 NF-κB 信号通路相互作用的模式，以控制植物的命运。用于癌症导向干预的肿瘤细胞。已知几种天然药效团可抑制 NF-κB 的核转位以及相关的促炎反应和细胞存活途径。鉴于这一点以及各种植物化学物质对 NF-κB 成分表现出的高度特异性，我们在此深入概述了这些植物化学物质，并讨论了它们与 NF-κB 信号通路相互作用的模式，以控制植物的命运。用于癌症导向干预的肿瘤细胞。已知几种天然药效团可抑制 NF-κB 的核转位以及相关的促炎反应和细胞存活途径。鉴于这一点以及各种植物化学物质对 NF-κB 成分表现出的高度特异性，我们在此深入概述了这些植物化学物质，并讨论了它们与 NF-κB 信号通路相互作用的模式，以控制植物的命运。用于癌症导向干预的肿瘤细胞。