While some diseases reduce fibrinogen concentration, others increase the amount of this clotting factor in the blood. Some studies have shown that the fibrinogen concentration in the blood is related to the stiffness of the formed clot. Hence, the aim of this study was to employ an ultrasonic method based on impulsive acoustic radiation force (IARF) to identify the fibrinogen concentration (coagulation factor I) in a plasma sample by means of peak-displacement (PD), time of peak-displacement (TPD), and shear modulus (μ) as well as to identify the change of plasma samples during the clot formation process. The IARF-based ultrasonic system transmitted bursts with a frequency of 2.03 MHz, duration of 246.31 µs, amplitude of 118 V_PP, and pulse with 1.25 Hz repetition frequency to generate an IARF on a glass sphere (2.99 mm in diameter and 2500 kg/m³ in density) embedded in a plasma sample, causing a displacement that was monitored by a pulse-echo system with a center frequency of 4.89 MHz. The values of the shear moduli were 124.14 ± 3.02, 556.99 ± 11.76, and 670.39 ± 9.77 Pa, for fibrinogen concentrations of 1.2, 2.4, and 3.6 g/L 20 to 36 min after the beginning of the coagulation process. The TPD values obtained in the same period were 5.28 ± 0.09, 3.03 ± 0.02, and 2.83 ± 0.01 s. The results indicate that an IARF-based ultrasonic system can be used clinically because it uses small amounts of plasma and has the ability to detect differences in PD, TPD, and μ as a function of fibrinogen concentrations.

虽然有些疾病会降低纤维蛋白原浓度，但其他疾病会增加血液中这种凝血因子的含量。一些研究表明，血液中的纤维蛋白原浓度与所形成的凝块的硬度有关。因此，本研究的目的是采用基于脉冲声辐射力（IARF）的超声波方法，通过峰值位移（PD）、峰值时间来确定血浆样品中的纤维蛋白原浓度（凝血因子I）。位移 (TPD) 和剪切模量 (μ) 以及识别血浆样本在凝块形成过程中的变化。基于 IARF 的超声波系统发射频率为 2.03 MHz、持续时间为 246.31 µs、振幅为 118 V _PP的脉冲串和重复频率为 1.25 Hz 的脉冲，以在玻璃球（直径 2.99 mm、2500 kg/ m ³ （密度））嵌入等离子体样品中，引起位移，该位移由中心频率为 4.89 MHz 的脉冲回波系统监测。凝血过程开始后 20 至 36 分钟，纤维蛋白原浓度为 1.2、2.4 和 3.6 g/L，剪切模量值为 124.14 ± 3.02、556.99 ± 11.76 和 670.39 ± 9.77 Pa。同期获得的TPD值为5.28±0.09、3.03±0.02和2.83±0.01s。结果表明，基于 IARF 的超声系统可用于临床，因为它使用少量血浆，并且能够检测 PD、TPD 和 μ 作为纤维蛋白原浓度函数的差异。