Rheumatoid arthritis (RA) is characterized by systemic synovitis leading to joint destruction in which imbalances in pro-inflammatory and anti-inflammatory cytokines promote the induction of autoimmunity. Some pro-inflammatory cytokines can trigger the signaling pathways which responsible for immune-mediated inflammation in RA, and the activated signaling pathways produce pro-inflammatory cytokines, resulting in aggravation of RA. Hence, understanding of the signaling pathways and their inhibitors might be advantageous in the development of therapeutic targets and new drugs for RA. In the current review, we summarize the signaling pathways involved in the pathogenesis of RA as well as the potential role of specific inhibitors in its management. We hope this paper may serve a reference for future studies on signaling pathways implicated in the pathogenesis of RA and benefit the treatment of RA.

类风湿性关节炎 (RA) 的特征是导致关节破坏的全身性滑膜炎，其中促炎和抗炎细胞因子的失衡促进了自身免疫的诱导。一些促炎细胞因子可触发导致 RA 免疫介导炎症的信号通路，激活的信号通路产生促炎细胞因子，导致 RA 的加重。因此，了解信号通路及其抑制剂可能有利于 RA 治疗靶点和新药的开发。在当前的综述中，我们总结了 RA 发病机制中涉及的信号通路以及特定抑制剂在其管理中的潜在作用。