The etiology of inflammatory bowel disorders (IBDs) involves an interplay of genetic and environmental factors. While human genomic analyses and preclinical animal models have revealed critical IBD risk genes and circuits, environmental effects remain poorly defined. In this issue, He et al. (2021) begin to fill this gap by reporting a striking potential of widely used food colorants to cause IBD-like colitis in mice.

中文翻译：

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食用色素被当场抓获

炎症性肠病 (IBD) 的病因涉及遗传和环境因素的相互作用。虽然人类基因组分析和临床前动物模型已经揭示了关键的 IBD 风险基因和回路，但环境影响仍然不清楚。在这个问题上，He 等人。（2021 年）通过报告广泛使用的食品着色剂在小鼠中引起 IBD 样结肠炎的惊人潜力，开始填补这一空白。