Activation of thermogenic adipocytes, a process canonically driven by norepinephrine through β-adrenergic receptors, presents an appealing therapeutic approach to combat obesity. Recent work by Sveidahl Johansen et al., 2021 published in Cell has identified a noncanonical mechanism of brown adipocyte activation, in which lipolysis transcriptionally drives the constitutive activation of the G_s protein-coupled receptor, GPR3, to induce thermogenesis.

中文翻译：

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GPR3 点燃棕色脂肪

产热脂肪细胞的激活是一种典型的由去甲肾上腺素通过 β-肾上腺素能受体驱动的过程，它为对抗肥胖提供了一种有吸引力的治疗方法。Sveidahl Johansen 等人最近在 2021 年发表在Cell上的工作确定了棕色脂肪细胞激活的非典型机制，其中脂肪分解转录驱动 G _s蛋白偶联受体 GPR3的组成型激活，以诱导产热。