A 7-year-old girl with a history of Langerhans cell histiocytosis (LCH), in remission, presented with the sudden appearance of multiple, agminated nevi. Skin biopsy revealed a benign junctional nevus, without recurrence of LCH. Subsequent immunohistochemical testing of both the skin and iliac wing biopsies demonstrated a BRAF V600E mutation. MAPK pathway mutations have been implicated in both LCH and nevogenesis.

中文翻译：

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成功治疗的朗格汉斯细胞组织细胞增生症患者的爆发性痣

一名有朗格汉斯细胞组织细胞增生症 (LCH) 病史的 7 岁女孩在缓解期突然出现多发、肿胀的痣。皮肤活检显示良性交界处痣，无 LCH 复发。随后对皮肤和髂骨翼活检进行的免疫组织化学测试表明存在BRAF V600E突变。MAPK 通路突变与 LCH 和新生细胞发生有关。