Background: Dyslipidemia is one of the most commonly experienced metabolic disorders, and it is strongly related to atherosclerotic cardiovascular disease. Hypothyroidism is a clinical syndrome resulting from a deficiency of thyroid hormones. Several studies from developed countries provide evidence that the rate of hypothyroidism in dyslipidemic patients is higher, but there is a scarcity of data from Bangladesh. Objectives: The aim of this study was to evaluate the prevalence and determinants of hypothyroidism in the adult dyslipidemic Bangladeshi population. Method: We examined the thyroid function of outpatients who were advised for fasting lipid profile and who were found to be dyslipidemic at a tertiary care hospital in Savar, Bangladesh, by a cross-sectional study conducted from July 2016 to June 2017. A total of 200 outpatients aged 20–65 years were enrolled in this study. A standard questionnaire was used to take record of sociodemographic, socioeconomic, and behavioral features. Body mass index (BMI) and blood pressure were examined with standard procedures. Biochemical parameters, such as fasting lipid profile and thyroid function markers, thyroid-stimulating hormone (TSH) and free thyroxine (fT4), were determined using standard assay methods. A p value < 0.05 was considered to be statistically significant. Results: Among the participants, 56% were male and 44% were female. 11.5% of the dyslipidemic subjects had hypothyroidism, among which 9.5% had subclinical hypothyroidism and only 2% had overt hypothyroidism. We also found that serum mean ± SD levels of TSH were significantly higher in the obese group of patients (p = 0.02). There was a significantly positive association of BMI and diastolic blood pressure with serum levels of TSH (p < 0.01) and fT4 (p = 0.02), respectively. Conclusion: Dyslipidemic patients should have more regular checkups. The findings of this study might be helpful in setting up the clinical management of dyslipidemias with or without normal thyroid function.

中文翻译：

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孟加拉国血脂异常患者甲状腺功能减退的程度和决定因素：一项基于医院的横断面研究

背景：血脂异常是最常见的代谢紊乱之一，与动脉粥样硬化性心血管疾病密切相关。甲状腺功能减退症是一种由甲状腺激素缺乏引起的临床综合征。发达国家的多项研究提供证据表明，血脂异常患者的甲状腺功能减退症发生率较高，但孟加拉国的数据缺乏。目的：本研究的目的是评估孟加拉国血脂异常成人人群中甲状腺功能减退症的患病率和决定因素。方法：我们通过 2016 年 7 月至 2017 年 6 月进行的横断面研究，检查了在孟加拉国萨瓦尔的一家三级医院接受空腹血脂检查并发现血脂异常的门诊患者的甲状腺功能。本研究共招募了 200 名 20-65 岁的门诊患者。使用标准问卷记录社会人口、社会经济和行为特征。用标准程序检查体重指数（BMI）和血压。生化参数，例如空腹血脂和甲状腺功能标志物、促甲状腺激素 (TSH) 和游离甲状腺素 (fT4)，使用标准测定方法确定。p 值 < 0.05 被认为具有统计学意义。结果：在参与者中，56% 是男性，44% 是女性。11.5%的血脂异常受试者有甲状腺功能减退症，其中9.5%有亚临床甲状腺功能减退症，只有2%有明显甲状腺功能减退症。我们还发现肥胖患者组中 TSH 的血清平均值 ± SD 水平显着更高（p = 0.02）。BMI 和舒张压分别与血清 TSH (p < 0.01) 和 fT4 (p = 0.02) 水平呈显着正相关。结论：血脂异常患者应加强定期检查。这项研究的结果可能有助于建立正常或不正常甲状腺功能的血脂异常的临床管理。