Background: The prevalence of common aeroallergen sensitization in subjects with AR and clinical comparison between AR and Non-AR (NAR) subjects in Thailand remains limited. The primary objective of this study was to illustrate the prevalence of the common aeroallergen sensitization in AR subjects and the differences in clinical characteristics between AR and NAR subjects.
Methods: Data were retrospectively collected from all subjects with chronic rhinitis who have visited the Chest and Allergy Clinic in three settings in Chiang Mai, Thailand between January 1998 and December 2018. Clinical characteristics and the result of skin prick test (SPT) to common aeroallergen were collected.
Results: A total of 2164 subjects with chronic rhinitis were enrolled, SPT was performed in 1001 (46.3%); 655 (65.4%) and 346 (34.6%) were AR and NAR, respectively. Mite mixed was the most frequent aeroallergen sensitization in subjects with AR both without asthma and with asthma (86.4% and 85.6%) followed by cockroach mixed (54.4% and 58.9%), grass pollen (38.9% and 40.4%), animal dander (15.5% and 19.9%), and mold mixed (5.7% and 11.0%). Polysensitization was higher in younger adults compared to middle aged adult and older adult (72.5%, 67.4%, and 58.7%, respectively, p=0.041). The AR subjects had lower age, earlier age of disease onset, and longer duration of disease (32.6± 16.3 vs 40.2± 15.4 years, 24 (10– 36) vs 34 years (22– 45), 3 (1– 10) vs 2 years (0– 5), respectively, p< 0.001). The AR subjects also had more asthma, conjunctivitis, and family history of chronic rhinitis (22.3% vs 15.6%, 25.3% vs 4.3%, and 58.0% vs 43.3%, respectively, p< 0.05).
Conclusion: The most common aeroallergen for AR (with and without asthma) was mite mixed followed by cockroach mixed and grass pollen. Polysensitization was significant higher in younger adult than middle aged and older adult. AR was significantly associated with asthma, conjunctivitis and family history of chronic rhinitis compared to NAR.



中文翻译：

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泰国清迈慢性鼻炎患者的空气过敏原致敏和临床特征：一项 20 年回顾性研究

背景：泰国 AR 和非 AR (NAR) 受试者之间的常见气源性过敏原致敏率仍然有限。本研究的主要目的是说明 AR 受试者中常见气源性过敏原致敏的普遍性以及 AR 和 NAR 受试者之间临床特征的差异。
方法：回顾性收集 1998 年 1 月至 2018 年 12 月期间在泰国清迈三个地点访问过胸部和过敏诊所的所有慢性鼻炎受试者的数据。临床特征和常见气性过敏原皮肤点刺试验 (SPT) 结果被收集。
结果：共纳入慢性鼻炎患者2164例，进行SPT 1001例（46.3%）；655 (65.4%) 和 346 (34.6%) 分别为 AR 和 NAR。在无哮喘和有哮喘的 AR 受试者中，螨虫混合是最常见的气源性过敏原致敏（86.4% 和 85.6%），其次是混合蟑螂（54.4% 和 58.9%）、草花粉（38.9% 和 40.4%）、动物皮屑（ 15.5% 和 19.9%），以及霉菌混合（5.7% 和 11.0%）。与中年人和老年人相比，年轻人的多敏性更高（分别为 72.5%、67.4% 和 58.7%，p=0.041）。AR 受试者年龄较小，发病年龄较早，病程较长（32.6±16.3 对 40.2±15.4 岁，24（10-36）对 34 岁（22-45），3（1-10）对分别为 2 年 (0-5)，p<0.001)。AR 受试者也有更多的哮喘、结膜炎、
结论： AR（伴有和不伴有哮喘）最常见的气源性过敏原是螨虫混合，其次是蟑螂混合和草花粉。年轻人的多敏性显着高于中年和老年人。与 NAR 相比，AR 与哮喘、结膜炎和慢性鼻炎家族史显着相关。