Hyperglycaemia-associated macrophage pyroptosis accelerates periodontal inflamm-aging,Journal of Clinical Periodontology

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Hyperglycaemia-associated macrophage pyroptosis accelerates periodontal inflamm-aging
Journal of Clinical Periodontology ( IF 6.7 ) Pub Date : 2021-07-04 , DOI: 10.1111/jcpe.13517
Pengfei Zhao _{1,

2} , Ziqi Yue _{1,

2} , Lulingxiao Nie _{1,

2} , Zhihao Zhao ₁ , Qian Wang _{1,

2} , Jiao Chen ₁ , Qi Wang _{1,

2}

Affiliation

Pyroptosis and inflamm-aging have been newly identified to be involved in diabetic periodontitis. This study aimed to elucidate whether macrophage pyroptosis plays a role in periodontal inflamm-aging by impacting the senescence of fibroblasts, as well as the potential mechanism via NLR family CARD domain-containing protein 4 (NLRC4) phosphorylation.

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