Management of constrictive pericarditis is often clinically challenging. Heart rate (HR) modulation using ivabradine is associated with improved clinical outcomes in patients with systolic heart failure, although it remains uninvestigated for other clinical purposes. We aimed to assess the impact of HR control in patients with constrictive pericarditis. In this retrospective study, consecutive patients who were diagnosed with constrictive pericarditis were included. Transthoracic echocardiography was performed at index discharge (day 0). The impact of HR difference between actual HR and ideal HR, which was calculated using a formula consisting of deceleration time, on heart failure readmission rates was investigated. A total of 15 patients (73 years old on median, 11 men) with constrictive pericarditis were included. On median, actual HR was 71 bpm and ideal HR was 81 bpm. Heart failure readmission rates were stratified into three groups by the HR difference: (1) optimal HR group satisfying "−10 bpm ≤ HR difference ≤ 10 bpm" (n = 4, 0.067 events per year); (2) lower HR group satisfying "HR difference < −10 bpm" (n = 7, 0.118 events per year, incidence rate ratio 1.98, 95% confidence interval 0.06-61.6); (3) higher HR group satisfying "HR difference > 10 bpm" (n = 4, 0.231 events per year, incidence rate ratio 9.22, 95% confidence interval 0.36-237.8). In conclusion, non-optimized HR was associated with an increased risk of heart failure recurrence in patients with constrictive pericarditis. Prospective assessment of deceleration time-guided HR optimization in patients with constrictive pericarditis is needed.

缩窄性心包炎的治疗在临床上通常具有挑战性。使用伊伐布雷定调节心率 (HR) 与改善收缩性心力衰竭患者的临床结果相关，尽管它尚未用于其他临床目的的研究。我们旨在评估 HR 控制对缩窄性心包炎患者的影响。在这项回顾性研究中，连续纳入了被诊断为缩窄性心包炎的患者。经胸超声心动图在首次出院时（第 0 天）进行。研究了实际 HR 与理想 HR 之间的 HR 差异对心力衰竭再入院率的影响，该差异使用由减速时间组成的公式计算。共纳入 15 名缩窄性心包炎患者（中位年龄 73 岁，男性 11 名）。在中位数上，实际心率为 71 bpm，理想心率为 81 bpm。根据 HR 差异将心力衰竭再入院率分为三组：（1）满足“-10 bpm ≤ HR 差异 ≤ 10 bpm”的最佳 HR 组（n = 4，每年 0.067 个事件）；(2)满足“HR差异<-10 bpm”的较低HR组（n =7，每年0.118次事件，发生率比1.98，95%置信区间0.06-61.6）；(3)满足“HR差异> 10 bpm”的较高HR组（n = 4，每年0.231事件，发生率比9.22，95%置信区间0.36-237.8）。总之，非优化 HR 与缩窄性心包炎患者心力衰竭复发风险增加有关。需要对缩窄性心包炎患者减速时间引导的 HR 优化进行前瞻性评估。