Are antibodies to fine specificities of citrullinated peptides/proteins useful for stratification of rheumatoid arthritis patients?,Clinical & Translational Immunology

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Are antibodies to fine specificities of citrullinated peptides/proteins useful for stratification of rheumatoid arthritis patients?
Clinical & Translational Immunology ( IF 4.6 ) Pub Date : 2021-07-05 , DOI: 10.1002/cti2.1288
Leonor Nogueira ₁ , Emilie Parra ₁ , Margaux Larrieu ₁ , Evelyne Verrouil ₁ , Martin Cornillet ₁

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In rheumatoid arthritis (RA), antibodies to citrullinated protein (ACPA) are believed to be heterogeneous and patient stratification by antibody profiling raised clinical interest for patient management. However, heterogeneity might be partially artificial because of the use of heterogeneous methods for ACPA detection. In recent work instead, we found that ACPA were mainly directed towards a single fibrin-derived peptide, β60-74BiotNt, but a comparative analysis with the presence of other ACPA specificities is still lacking.

中文翻译：

瓜氨酸肽/蛋白质的精细特异性抗体对类风湿性关节炎患者的分层有用吗？

在类风湿性关节炎 (RA) 中，抗瓜氨酸蛋白 (ACPA) 的抗体被认为是异质的，通过抗体分析对患者进行分层提高了临床对患者管理的兴趣。然而，由于 ACPA 检测使用了异质性方法，异质性可能部分是人为的。相反，在最近的工作中，我们发现 ACPA 主要针对单个纤维蛋白衍生肽 β60-74BiotNt，但仍然缺乏与其他 ACPA 特异性存在的比较分析。

更新日期：2021-07-05

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