Impaired elimination of toxic compounds via inadequate sulfation may contribute to the pathogenesis of primary sclerosing cholangitis (PSC). Dehydroepiandrosterone (DHEA) is metabolized into its sulfated form (DHEA-S) in the liver. DHEA has also been linked with health-related quality of life (HRQoL) in various conditions.

中文翻译：

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硫酸脱氢表雄酮表明原发性硬化性胆管炎中硫酸化能力降低和生活质量受损。

通过不充分的硫酸化作用损害有毒化合物的消除可能有助于原发性硬化性胆管炎 (PSC) 的发病机制。脱氢表雄酮 (DHEA) 在肝脏中代谢成硫酸盐形式 (DHEA-S)。DHEA 还与各种情况下的健康相关生活质量 (HRQoL) 相关联。