Fighting antimicrobial resistance (AMR): Chinese herbal medicine as a source of novel antimicrobials – an update,Letters in Applied Microbiology

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Fighting antimicrobial resistance (AMR): Chinese herbal medicine as a source of novel antimicrobials – an update
Letters in Applied Microbiology ( IF 2.0 ) Pub Date : 2021-07-05 , DOI: 10.1111/lam.13534
B C Millar _{1,

2} , J R Rao ₃ , J E Moore _{1,

2}

Affiliation

Antimicrobial resistance (AMR) has now emerged as a global public health crisis, requiring the discovery of new and novel antimicrobial compounds, that may be precursors of future therapeutic antibiotics. Chinese Herbal Medicine (CHM) comes with a rich pedigree of holistic and empirical usage in Asia for the last 5000 years. Extracts of Anemarrhena asphodeloides Bunge, Angelica sinensis (Oliv.) Diels, Dianthus superbus L. Forsythiae fructus (Lian Qiao), Lonicerae flos (Jin Yin Hua), Naemorhedi cornu, Platycladus orientalis Franco, Polygonum aviculare, Polygonum cuspidatum, Poria cocos (Schw.), Rehmannia glutinosa (Gaertn.) DC, Rheum palmatum, Salvia miltiorrhiza Bunge, Scutellaria barbata, Scutellariae radix (Huang Qin) and Ursi fel (Xiong Dan) have shown to have antimicrobial properties against clinically significant Gram-negative and Gram-positive bacterial pathogens, as well as the mycobacteria (TB and non-tuberculous mycobacteria). Evidence is now beginning to emerge through systematic reviews of the outcomes of clinical studies employing CHM to treat infections. Of the 106 Cochrane systematic reviews on CHM, 16 (ca 15%) reviews examine CHM in the context of treating a specific infection disease or state. This update examines direct antimicrobial effect of CHM on bacterial pathogens, as well as synergistic effects of combining CHM with conventional antibiotics.

中文翻译：

抗击抗菌素耐药性 (AMR)：中草药作为新型抗菌素的来源——更新

抗微生物药物耐药性 (AMR) 现在已成为全球公共卫生危机，需要发现新的和新颖的抗微生物化合物，这些化合物可能是未来治疗性抗生素的前体。过去 5000 年来，中草药 (CHM) 在亚洲拥有丰富的整体和经验使用谱系。提取物知母邦吉，当归（杜仲）的Diels，瞿麦L.连翘（莲俏），金银花（市斤尹华），Naemorhedi大角，侧柏佛朗哥，萹蓄，虎杖，茯苓（SCHW .),Rehmannia glutinosa (Gaertn.) DC、Rheum palmatum、Salvia miltiorrhiza Bunge、Scutellaria barbata、Scutellariae radix (Huang Qin) 和Ursi fel (Xiong Dan) 已显示出对临床上显着的革兰氏阴性和革兰氏阳性细菌病原体的抗菌特性，以及分枝杆菌（结核病和非结核分枝杆菌）。通过对使用 CHM 治疗感染的临床研究结果的系统评价，证据现在开始出现。在 106 篇关于 CHM 的 Cochrane 系统评价中，16 篇（约15%) 评论在治疗特定感染疾病或状态的背景下检查 CHM。此更新检查了 CHM 对细菌病原体的直接抗菌作用，以及 CHM 与常规抗生素结合的协同作用。

更新日期：2021-07-05

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