There is a close relationship between the kidney and blood pressure. On the one hand, kidney dysfunction causes an increase in blood pressure; on the other hand, high blood pressure causes kidney dysfunction. Wnt/β-catenin signaling is a key pathway that regulates various cellular processes and tissue homeostasis and is also involved in damage and repair processes. In healthy organs, Wnt/β-catenin signaling is muted, but it is activated in pathological states. The purpose of the present study was to immunohistochemically evaluate and compare the expression of WNT4, WNT10A, Fzd8, β-catenin, and GSK-3ß (glycogen synthase kinase 3β) in the kidneys of rats with essential arterial hypertension (SHR), renal–renal hypertension (2K1C), and DOCA-salt-induced hypertension. The study was performed on five male WKY rats, seven SHRs, and twenty-four (n = 24) young male Wistar rats. The main results showed that during hypertension, there are changes in Wnt/β-catenin signaling in the kidneys of rats, and the severity of these changes depends on the type of hypertension. This study is the first to assess the levels of some elements of the canonical Wnt/β-catenin signal transduction pathway in various types of arterial hypertension by immunohistochemistry and may form the basis for further molecular and functional studies of this pathway in hypertension.

肾脏与血压有着密切的关系。一方面，肾功能不全导致血压升高；另一方面，高血压会导致肾功能障碍。Wnt/β-连环蛋白信号通路是调节各种细胞过程和组织稳态的关键通路，也参与损伤和修复过程。在健康器官中，Wnt/β-连环蛋白信号被抑制，但在病理状态下被激活。本研究的目的是通过免疫组织化学方法评估和比较原发性动脉高血压 (SHR)、肾-肾性高血压 (2K1C) 和 DOCA 盐引起的高血压。该研究是在五只雄性 WKY 大鼠、七只 SHR 和二十四只（n  = 24) 年轻的雄性 Wistar 大鼠。主要结果表明，在高血压期间，大鼠肾脏中的 Wnt/β-catenin 信号发生变化，这些变化的严重程度取决于高血压的类型。本研究首次通过免疫组织化学评估各种类型动脉高血压中经典 Wnt/β-catenin 信号转导通路中某些元素的水平，并可能为进一步对该通路在高血压中的分子和功能研究奠定基础。