The vascular and neurodegenerative processes related to clinical dementia cause cell loss which induces, amongst others, an increase in interstitial fluid (ISF).

We assessed microvascular, parenchymal integrity, and a proxy of ISF volume alterations with intravoxel incoherent motion imaging in 21 healthy controls and 53 memory clinic patients – mainly affected by neurodegeneration (mild cognitive impairment, Alzheimer's disease dementia), vascular pathology (vascular cognitive impairment), and presumed to be without significant pathology (subjective cognitive decline).

The microstructural components were quantified with spectral analysis using a non-negative least squares method. Linear regression was employed to investigate associations of these components with hippocampal and white matter hyperintensity (WMH) volumes. In the normal appearing white matter, a large f_int (a proxy of ISF volume) was associated with a large WMH volume and low hippocampal volume. Likewise, a large f_int value was associated with a lower hippocampal volume in the hippocampi.

Large ISF volume (f_int) was shown to be a prominent factor associated with both WMHs and neurodegenerative abnormalities in memory clinic patients and is argued to play a potential role in impaired glymphatic functioning.

与临床痴呆相关的血管和神经退行性过程会导致细胞丢失，从而导致间质液 (ISF) 增加等。

我们评估了 21 名健康对照者和 53 名记忆诊所患者的微血管、实质完整性和 ISF 体积变化的代表，这些患者主要受神经变性（轻度认知障碍、阿尔茨海默病痴呆）、血管病理学（血管认知障碍）的影响，并且假定没有明显的病理（主观认知能力下降）。

使用非负最小二乘法通过光谱分析对微观结构成分进行量化。采用线性回归来研究这些成分与海马和白质高信号 (WMH) 体积的关联。在正常出现的白质中，大f _int（ISF 体积的代表）与大 WMH 体积和低海马体积相关。同样，较大的f _int值与海马中较低的海马体积相关。

大 ISF 体积 ( f _int ) 被证明是与 WMH 和记忆临床患者神经退行性异常相关的重要因素，并被认为在受损的淋巴系统功能中发挥潜在作用。