Pharmaceutical drugs have emerged as major micropollutants in aquatic ecosystems. Their presence has been systematically reported in monitoring surveys, and their wide distribution and constant presence in the wild is a direct consequence of their massive use, in both human and veterinary therapeutics. Drugs used to treat parasitic infections in livestock are major contaminants, given the amounts in which they are administered, and reach the aquatic compartment in high amounts, where they may affect non target species. Some of these drugs are prone to find their final deposit in sediments of estuarine areas, exerting their toxic effects preferentially at these locations. Sediment dwelling organisms of coastal areas, such as polychaetas, are especially prone to have their major physiological functions compromised after being exposed to pharmaceutical drugs. Ivermectin is one of the most used antiparasitic drugs, and its effects are not limited to biochemical traits, but also behavioral features may be compromised considering their neurotoxic actions. Despite these putative effects, little is known about their toxicity on polychaetas. The present study aimed to characterize the toxicity of realistic levels of ivermectin on the polychaeta Hediste diversicolor, in biochemical and behavioral terms. The obtained results showed that low levels of ivermectin are capable of causing significant disturbances in mobility and burrowing activity of exposed worms, as well as alterations of metabolic and anti-oxidant defense efficacy of exposed animals, suggesting that its environmental presence may mean a major environmental concern.

药物已成为水生生态系统中的主要微污染物。在监测调查中系统地报告了它们的存在，它们在野外的广泛分布和持续存在是它们在人类和兽医治疗中大量使用的直接结果。用于治疗牲畜寄生虫感染的药物是主要污染物，考虑到它们的给药量，并且大量到达水生隔间，在那里它们可能影响非目标物种。这些药物中的一些容易在河口地区的沉积物中找到它们的最终沉积物，优先在这些位置发挥其毒性作用。沿海地区的沉积物栖息生物，如多毛类、在接触药物后，他们的主要生理功能特别容易受到损害。伊维菌素是最常用的抗寄生虫药物之一，其作用不仅限于生化特征，而且考虑到其神经毒性作用，行为特征也可能受到影响。尽管有这些假定的影响，但对其对多毛类的毒性知之甚少。本研究旨在表征实际水平的伊维菌素对多毛类动物的毒性。Hediste diversicolor，在生化和行为方面。获得的结果表明，低水平的伊维菌素能够对暴露的蠕虫的活动性和穴居活动造成显着干扰，以及暴露动物的代谢和抗氧化防御功效的改变，表明其环境存在可能意味着一个主要的环境忧虑。