Osteoarthritis (OA) affects about 90% of dogs > 5 yr of age in the United States, resulting in reduced range of motion, difficulty climbing and jumping, reduced physical activity, and lower quality of life. Our objective was to use activity monitors to measure physical activity and identify how activity counts correlate with age, body weight (BW), body condition score (BCS), serum inflammatory markers, veterinarian pain assessment, and owner perception of pain in free-living dogs with OA. The University of Illinois Institutional Animal Care and Use Committee approved the study and owner consent was received prior to experimentation. Fifty-six client-owned dogs (mean age = 7.8 yr; mean BCS = 6.1) with clinical signs and veterinary diagnosis of OA wore HeyRex activity collars continuously over a 49-d period. Blood samples were collected on day 0 and 49, and dog owners completed canine brief pain inventory (CBPI) and Liverpool osteoarthritis in dogs (LOAD) surveys on day 0, 21, 35, and 49. All data were analyzed using SAS 9.3 using repeated measures and R Studio 1.0.136 was used to generate Pearson correlation coefficients between data outcomes. Average activity throughout the study demonstrated greater activity levels on weekends. It also showed that 24-h activity spiked twice daily, once in the morning and another in the afternoon. Serum C-reactive protein concentration was lower (P < 0.01) at day 49 compared to day 0. Survey data indicated lower (P < 0.05) overall pain intensity and severity score on day 21, 35 and 49 compared to day 0. BW was correlated with average activity counts (P = 0.02; r = −0.12) and run activity (P = 0.10; r = −0.24). Weekend average activity counts were correlated with owner pain intensity scores (P = 0.0813; r = −0.2311), but weekday average activity count was not. Age was not correlated with total activity count, sleep activity, or run activity, but it was correlated with scratch (P = 0.03; r = −0.10), alert (P = 0.03; r = −0.13), and walk (P = 0.09; r = −0.23) activities. Total activity counts and activity type (sleep, scratch, alert, walk, and run) were not correlated with pain scored by veterinarians, pain intensity or severity scored by owners, or baseline BCS. Even though the lack of controls and/or information on the individual living conditions of dogs resulted in a high level of variability in this study, our data suggest that the use of activity monitors have the potential to aid in the management of OA and other conditions affecting activity (e.g., allergy; anxiety).

中文翻译：

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被诊断患有骨关节炎的自由生活犬的体力活动模式

骨关节炎 (OA) 影响约 90% 的狗 > 在美国 5 岁，导致运动范围减小、攀爬和跳跃困难、体力活动减少和生活质量降低。我们的目标是使用活动监测器来测量身体活动，并确定活动计数与年龄、体重 (BW)、身体状况评分 (BCS)、血清炎症标志物、兽医疼痛评估和所有者对自由生活疼痛的感知有何关联患有 OA 的狗。伊利诺伊大学机构动物护理和使用委员会批准了该研究，并在实验前获得了所有者的同意。56 只客户拥有的狗（平均年龄 = 7.8 岁；平均 BCS = 6.1）具有 OA 的临床症状和兽医诊断，在 49 天期间连续佩戴 HeyRex 活动项圈。在第 0 天和第 49 天收集血样，狗主人在第 0、21、35 和 49 天完成了犬类短暂疼痛清单 (CBPI) 和利物浦犬骨关节炎 (LOAD) 调查。所有数据均使用 SAS 9.3 重复使用测量和 R Studio 1.0.136 用于生成数据结果之间的 Pearson 相关系数。整个研究中的平均活动表明周末的活动水平更高。它还显示 24 小时活动每天两次飙升，一次在早上，另一次在下午。与第 0 天相比，第 49 天的血清 C 反应蛋白浓度较低 (P < 0.01)。调查数据表明，与第 0 天相比，第 21、35 和 49 天的总体疼痛强度和严重程度评分较低 (P < 0.05)。体重与平均活动计数（P = 0.02；r = -0.12）和跑步活动（P = 0.10；r = -0.24）。周末平均活动计数与所有者疼痛强度评分相关（P = 0.0813；r = -0.2311），但工作日平均活动计数与此无关。年龄与总活动计数、睡眠活动或跑步活动无关，但与抓挠（P = 0.03；r = -0.10）、警觉（P = 0.03；r = -0.13）和步行（P = 0.09；r = -0.23) 活动。总活动计数和活动类型（睡眠、抓挠、警觉、步行和跑步）与兽医评分的疼痛、所有者评分的疼痛强度或严重程度或基线 BCS 无关。尽管缺乏对狗个体生活条件的控制和/或信息导致本研究存在高度可变性，