Developmental endothelial locus-1 (Del-1) is a secretory, multifunctional domain protein. It can bind to integrins and phosphatidylserine. As a local tissue signal, it plays a regulatory role in the cancer microenvironment and inflammation. Del-1 has destructive effects in most cancers and is associated with the progression and invasion of some cancers. In contrast, Del-1 also plays a protective role in inflammation. Del-1 regulates inflammation by regulating the generation of neutrophils in bone marrow, inhibiting the recruitment and migration of neutrophils and accelerating the clearance of neutrophils by macrophages. Del-1 and IL-17 are reciprocally regulated, and their balance maintains immune system homeostasis. Del-1 is expected to become a new therapeutic target for inflammatory disorders such as multiple sclerosis.

中文翻译：

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局部组织信号 Del-1 在癌症和炎症中的调节作用：综述

发育内皮基因座-1 (Del-1) 是一种分泌型多功能域蛋白。它可以与整联蛋白和磷脂酰丝氨酸结合。作为局部组织信号，它在癌症微环境和炎症中发挥调节作用。Del-1 在大多数癌症中具有破坏性作用，并且与某些癌症的进展和侵袭有关。相比之下，Del-1 在炎症中也起保护作用。Del-1通过调节骨髓中中性粒细胞的产生、抑制中性粒细胞的募集和迁移以及加速巨噬细胞对中性粒细胞的清除来调节炎症。Del-1 和 IL-17 相互调节，它们的平衡维持免疫系统的稳态。Del-1有望成为多发性硬化等炎症性疾病的新治疗靶点。