Coronary artery disease (CAD) is a dilemma and a serious cause of morbidity and mortality worldwide. Since CAD has been seen in people without the conventional risk factors like smoking, diabetes, and hypertension, the infectious theory being a risk factor has arisen. Helicobacter pylori (HP) infection is the most common infection affecting the vast majority of the population worldwide. HP grows in the gastrointestinal tract (GIT) and responsible for chronic gastritis, peptic ulcer, gastric adenocarcinoma, and gastric lymphoma. A review of medical literature mainly PubMed has revealed several studies reporting that HP pathogenesis extends beyond the GIT to be a predisposing factor for atherosclerosis, dyslipidemia, thrombosis, and CAD. However, it remains a controversial issue that warrants extensive research. This article gives insight into the diversity of opinions, evidence, and theories regarding the association between HP infection and CAD. The idea that CAD may be managed with antibiotics in certain patients seems to be creative and inspiring. More research is mandatory to either verify or reject this proposed correlation with strong scientific evidence and also to demonstrate the implications of the results on CAD management and outcome.

中文翻译：

---

幽门螺杆菌感染与冠状动脉疾病的关系：它是一个独立的危险因素吗？

冠状动脉疾病 (CAD) 是一个两难境地，是全世界发病率和死亡率的严重原因。由于 CAD 出现在没有传统危险因素（如吸烟、糖尿病和高血压）的人群中，因此出现了作为危险因素的传染性理论。幽门螺杆菌 (HP) 感染是影响全世界绝大多数人口的最常见感染。HP 在胃肠道 (GIT) 中生长，导致慢性胃炎、消化性溃疡、胃腺癌和胃淋巴瘤。主要是 PubMed 的医学文献回顾显示，几项研究报告称，HP 发病机制超出了 GIT，成为动脉粥样硬化、血脂异常、血栓形成和 CAD 的易感因素。然而，这仍然是一个有争议的问题，需要进行广泛的研究。本文深入了解关于 HP 感染与 CAD 之间关联的各种观点、证据和理论。在某些患者中可以使用抗生素治疗 CAD 的想法似乎具有创造性和启发性。必须进行更多的研究来验证或拒绝这种与强有力的科学证据的相关性，并证明结果对 CAD 管理和结果的影响。