The Jumonji domain-containing protein-3 (JMJD3) is a histone demethylase that regulates the trimethylation of histone H3 on lysine 27 (H3K27me3). H3K27me3 is an important epigenetic event associated with transcriptional silencing. JMJD3 has been studied extensively in immune diseases, cancer, and tumor development. There is a comprehensive epigenetic transformation during the transition of embryonic stem cells (ESCs) into specialized cells or the reprogramming of somatic cells to induced pluripotent stem cells (iPSCs). Recent studies have illustrated that JMJD3 plays a major role in cell fate determination of pluripotent and multipotent stem cells (MSCs). JMJD3 has been found to enhance self-renewal ability and reduce the differentiation capacity of ESCs and MSCs. In this review, we will focus on the recent advances of JMJD3 function in stem cell fate.

中文翻译：

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JMJD3：干细胞命运中的关键表观遗传调节因子

含有 Jumonji 结构域的蛋白 3 (JMJD3) 是一种组蛋白去甲基化酶，可调节组蛋白 H3 在赖氨酸 27 (H3K27me3) 上的三甲基化。H3K27me3 是与转录沉默相关的重要表观遗传事件。JMJD3 已在免疫疾病、癌症和肿瘤发展中得到广泛研究。在胚胎干细胞 (ESC) 转变为特化细胞或体细胞重编程为诱导多能干细胞 (iPSC) 期间，会发生全面的表观遗传转化。最近的研究表明，JMJD3 在多能和多能干细胞 (MSCs) 的细胞命运决定中起主要作用。已发现 JMJD3 可增强 ESCs 和 MSCs 的自我更新能力并降低其分化能力。在本次审查中，