We read the article by Ahmad et al¹ with great interest. The study concluded that endoxifen is efficacious and safe in patients with acute manic episodes with/without mixed features. However, we are worried about internal and external validity of study results.

中文翻译：

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Endoxifen（一种蛋白激酶 C 抑制剂）对急性和混合性躁狂症的疗效：一些值得考虑的问题

我们怀着极大的兴趣阅读了 Ahmad 等人^{1的文章。}该研究得出结论，endoxifen 对伴有/不伴有混合特征的急性躁狂发作患者有效且安全。然而，我们担心研究结果的内部和外部有效性。