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Real-Time Functional Assay of Volumetric Muscle Loss Injured Mouse Masseter Muscles via Nanomembrane Electronics
Advanced Science ( IF 14.3 ) Pub Date : 2021-07-03 , DOI: 10.1002/advs.202101037 Hojoong Kim 1, 2 , Young-Tae Kwon 3 , Carol Zhu 4 , Fang Wu 4 , Shinjae Kwon 1, 2 , Woon-Hong Yeo 1, 2, 5 , Hyojung J Choo 4
Advanced Science ( IF 14.3 ) Pub Date : 2021-07-03 , DOI: 10.1002/advs.202101037 Hojoong Kim 1, 2 , Young-Tae Kwon 3 , Carol Zhu 4 , Fang Wu 4 , Shinjae Kwon 1, 2 , Woon-Hong Yeo 1, 2, 5 , Hyojung J Choo 4
Affiliation
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Skeletal muscle has a remarkable regeneration capacity to recover its structure and function after injury, except for the traumatic loss of critical muscle volume, called volumetric muscle loss (VML). Although many extremity VML models have been conducted, craniofacial VML has not been well-studied due to unavailable in vivo assay tools. Here, this paper reports a wireless, noninvasive nanomembrane system that integrates skin-wearable printed sensors and electronics for real-time, continuous monitoring of VML on craniofacial muscles. The craniofacial VML model, using biopsy punch-induced masseter muscle injury, shows impaired muscle regeneration. To measure the electrophysiology of small and round masseter muscles of active mice during mastication, a wearable nanomembrane system with stretchable graphene sensors that can be laminated to the skin over target muscles is utilized. The noninvasive system provides highly sensitive electromyogram detection on masseter muscles with or without VML injury. Furthermore, it is demonstrated that the wireless sensor can monitor the recovery after transplantation surgery for craniofacial VML. Overall, the presented study shows the enormous potential of the masseter muscle VML injury model and wearable assay tool for the mechanism study and the therapeutic development of craniofacial VML.
中文翻译：
通过纳米膜电子器件对体积肌肉丢失受伤的小鼠咬肌进行实时功能分析
骨骼肌具有显着的再生能力，可以在受伤后恢复其结构和功能，但关键肌肉体积的创伤性损失除外，称为体积肌肉损失（VML）。尽管已经建立了许多四肢 VML 模型，但由于缺乏体内检测工具，颅面 VML 尚未得到充分研究。本文报告了一种无线、非侵入性纳米膜系统，该系统集成了皮肤可穿戴印刷传感器和电子设备，用于实时、连续监测颅面肌肉上的 VML。颅面 VML 模型采用活检穿孔引起的咬肌损伤，显示肌肉再生受损。为了测量活跃小鼠咀嚼过程中小而圆的咬肌的电生理学，使用了带有可拉伸石墨烯传感器的可穿戴纳米膜系统，该传感器可以层压到目标肌肉上的皮肤上。该无创系统可对有或没有 VML 损伤的咬肌进行高度灵敏的肌电图检测。此外，研究还证明无线传感器可以监测颅面VML移植手术后的恢复情况。总体而言，本研究表明咬肌 VML 损伤模型和可穿戴检测工具对于颅面 VML 的机制研究和治疗开发具有巨大潜力。
更新日期：2021-09-09
中文翻译：
通过纳米膜电子器件对体积肌肉丢失受伤的小鼠咬肌进行实时功能分析
骨骼肌具有显着的再生能力，可以在受伤后恢复其结构和功能，但关键肌肉体积的创伤性损失除外，称为体积肌肉损失（VML）。尽管已经建立了许多四肢 VML 模型，但由于缺乏体内检测工具，颅面 VML 尚未得到充分研究。本文报告了一种无线、非侵入性纳米膜系统，该系统集成了皮肤可穿戴印刷传感器和电子设备，用于实时、连续监测颅面肌肉上的 VML。颅面 VML 模型采用活检穿孔引起的咬肌损伤，显示肌肉再生受损。为了测量活跃小鼠咀嚼过程中小而圆的咬肌的电生理学，使用了带有可拉伸石墨烯传感器的可穿戴纳米膜系统，该传感器可以层压到目标肌肉上的皮肤上。该无创系统可对有或没有 VML 损伤的咬肌进行高度灵敏的肌电图检测。此外，研究还证明无线传感器可以监测颅面VML移植手术后的恢复情况。总体而言，本研究表明咬肌 VML 损伤模型和可穿戴检测工具对于颅面 VML 的机制研究和治疗开发具有巨大潜力。
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