ABSTRACT

Introduction: Acne vulgaris is a chronic inflammatory skin disorder that affects an extremely concerning percentage of teenagers (ca. 85%), gathering serious negative impacts on the social life and psychological well-being of individuals. Conventional topical formulations for acne show low tolerability and side effects, such as skin irritation, leading to a decrease in the user’s adherence to therapy. Nanotechnology-based formulations were developed as new strategies for topical acne management, particularly to overcome the difficulties associated with conventional treatments.

Areas covered: This paper presents a critical analysis of reviewed nanosized anti-acne technological strategies, strongly supporting controlled active ingredient release, improved skin permeation, and lower skin irritation. An updated regulatory framework, considering the promising applications in nanomedicine, and the toxicity of these nanosystems are also addressed.

Expert opinion: Nanosystems evidence several advantages, attending to the possibility of controlled active ingredient release, better skin permeation, and lower skin irritation. However, novel nanotechnological strategies for acne treatment and care can lead to new side effects, but also environmental nano pollution. Little is known about the toxicology of these nanotechnology-based formulations, therefore, as future trends, more studies should be conducted to assure the consumers’ health and environmental safety.

摘要

简介： 寻常痤疮是一种慢性炎症性皮肤病，影响青少年的比例非常高（约 85%），对个人的社交生活和心理健康造成严重的负面影响。用于痤疮的常规局部制剂显示出低耐受性和副作用，例如皮肤刺激，导致使用者对治疗的依从性降低。基于纳米技术的配方被开发为局部痤疮管理的新策略，特别是为了克服与传统治疗相关的困难。

涵盖的领域：本文对已审查的纳米级抗痤疮技术策略进行了批判性分析，强烈支持受控活性成分释放、改善皮肤渗透和降低皮肤刺激。考虑到纳米医学中的有前景的应用以及这些纳米系统的毒性，更新的监管框架也得到了解决。

专家意见：纳米系统证明了几个优点，注意控制活性成分释放、更好的皮肤渗透和降低皮肤刺激的可能性。然而，用于痤疮治疗和护理的新型纳米技术策略可能会导致新的副作用，也会导致环境纳米污染。对这些基于纳米技术的配方的毒理学知之甚少，因此，作为未来的趋势，应该进行更多的研究，以确保消费者的健康和环境安全。