18 F-fluorination using aluminum-fluoride ([ 18 F]AlF) chelate technique has been reported to give a low-to-moderate radiochemical yield, between 5 and 20%. Therefore, the work described here outlines the optimum 18 F-fluorination condition for the formation of [ 18 F]AlF 2+ and [ 18 F]AlF-NOTA-NHS complex with the radiochemical yield (RCY) and purity (RCP) of more than 90% as a prerequisite step before proceeding with the radiopharmaceutical preparation using the [ 18 F]AlF-bifunctional chelator technique. As well as being simple, the suggested method is practical and relevant for beginners interested in 18 F-fluorination with [ 18 F]AlF-chelate complex technique or also for a researcher who aims to proceed on an extensive scale.

中文翻译：

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[18F]AlF-NOTA-NHS复合物高放射化学产率的最佳18F-氟化条件

据报道，使用氟化铝 ([ 18 F]AlF) 螯合技术的 18 F-氟化可产生低至中等的放射化学产率，介于 5% 和 20% 之间。因此，这里描述的工作概述了形成 [ 18 F]AlF 2+ 和 [ 18 F]AlF-NOTA-NHS 复合物的最佳 18 F-氟化条件，其放射化学产率 (RCY) 和纯度 (RCP) 更高。在使用[ 18 F]AlF-双功能螯合剂技术进行放射性药物制备之前，作为先决步骤，超过 90%。除了简单之外，所建议的方法对于对使用 [ 18 F] AlF-螯合物技术进行 18 F-氟化感兴趣的初学者或旨在进行大规模研究的研究人员来说是实用且相关的。