Snus is one of the types of smokeless tobaccos, which is popular in many countries and regions. The nicotine level in the plasma samples obtained from snus users is similar to the nicotine level obtained from cigarette smokers; hence, the snus users find it difficult to quit. The aim of this study is to develop new semi-interpenetrating polymer (SIPN) membranes that control the stable release of nicotine from snus, achieving the purpose of quitting smoking. Here, the SIPN comprising a polyacrylate network and PEG chains was synthesized through in situ radical polymerization. The SIPN was characterized by Fourier transform infrared spectroscopy, contact angle, differential scanning calorimetry, scanning electron microscopy, cytotoxicity, and in vitro release experiments. Furthermore, this SIPN was used to evaluate the release properties of nicotine in different snus samples varying in moisture, pH, and the tobacco’s particle size. The results indicated that the new SIPN could control release of nicotine at a specific rate, and the release rate could be adjusted according to the customer requirements. Thus, the new SIPN was contributed to build a new nicotine replacement therapy that served the snus users.

中文翻译：

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SIPN膜控制鼻烟中尼古丁释放的研究

鼻烟是无烟烟草中的一种，在许多国家和地区都很流行。从鼻烟使用者获得的血浆样本中的尼古丁水平与从吸烟者身上获得的尼古丁水平相似；因此，鼻烟使用者很难戒掉。本研究的目的是开发新型半互穿聚合物（SIPN）膜，控制鼻烟中尼古丁的稳定释放，达到戒烟的目的。在这里，包含聚丙烯酸酯网络和 PEG 链的 SIPN 是通过原位自由基聚合合成的。SIPN 通过傅里叶变换红外光谱、接触角、差示扫描量热法、扫描电子显微镜、细胞毒性和体外释放实验进行表征。此外，该 SIPN 用于评估不同鼻烟样品中尼古丁的释放特性，这些样品的水分、pH 值和烟草颗粒大小各不相同。结果表明，新的SIPN可以控制特定速率的尼古丁释放，释放速率可以根据客户要求进行调整。因此，新的 SIPN 有助于建立一种新的尼古丁替代疗法，为鼻烟使用者提供服务。