A scalable synthesis of l-allo-enduracididine is achieved from commercially available (S)-glycidol in ten linear steps involving well-established synthetic transformations. The synthetic route is flexible and can be used to synthesize all four diastereomers by changing the stereochemistry of glycidol and Sharpless asymmetric dihydroxylation reagent.

中文翻译：

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l-allo-Enduracididine 的可扩展合成：Teixobactin 中存在的不寻常氨基酸

l-allo-enduracididine 的可扩展合成是从市售的 (S)-缩水甘油在十个线性步骤中实现的，这些步骤涉及完善的合成转化。合成路线灵活，通过改变缩水甘油和Sharpless不对称二羟基化试剂的立体化学，可用于合成所有四种非对映异构体。