Dengue is an arboviral infection endemic in tropical countries. Neurological sequelae to dengue infection are not uncommon, and psychiatric manifestations are increasingly reported. This narrative review aims to present the varied manifestations, postulated mechanisms, and the available treatment options for psychiatric morbidity associated with dengue. The evidence available from eight observational studies is summarized in this review. Depression and anxiety are noted to be prevalent during both the acute and convalescent stages of the infection. The presence of encephalopathy and other neurological conditions is not a prerequisite for developing psychiatric disorders. However, treatment options to manage such psychiatric manifestations were not specified in the observational studies. Anecdotal evidence from case reports is outlined. Special attention is paid to the role of epigenetic modifications following dengue infections and the role of histone deacetylase inhibitors in the management. DNA methylation inhibitors such as valproic acid play a significant role in reversing stress-, viral-, or drug-induced epigenetic modifications.

登革热是热带国家流行的虫媒病毒感染。登革热感染的神经系统后遗症并不少见，精神症状的报道也越来越多。这篇叙述性综述旨在介绍与登革热相关的精神疾病的各种表现、假设机制和可用的治疗方案。本综述总结了八项观察性研究提供的证据。抑郁和焦虑在感染的急性期和恢复期都很普遍。脑病和其他神经系统疾病的存在不是发展精神疾病的先决条件。然而，观察性研究并未具体说明管理此类精神症状的治疗方案。概述了来自病例报告的轶事证据。特别关注登革热感染后表观遗传修饰的作用以及组蛋白去乙酰化酶抑制剂在管理中的作用。DNA甲基化抑制剂如丙戊酸在逆转应激、病毒或药物诱导的表观遗传修饰中发挥着重要作用。