Aotearoa New Zealand Māori and Pacific population-specific gout risk variants: CLNK is a separate risk gene at the SLC2A9 locus.,The Journal of Rheumatology

当前位置： X-MOL 学术 › J. Rheumatol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Aotearoa New Zealand Māori and Pacific population-specific gout risk variants: CLNK is a separate risk gene at the SLC2A9 locus.
The Journal of Rheumatology ( IF 3.6 ) Pub Date : 2021-07-01 , DOI: 10.3899/jrheum.201684
Aichang Ji ₁ , Amara Shaukat ₂ , Riku Takei ₃ , Matthew Bixley ₂ , Murray Cadzow ₂ , Ruth K Topless ₂ , Tanya J Major ₂ , Amanda Phipps-Green ₂ , Marilyn E Merriman ₂ , Jennie Harré Hindmarsh ₄ , Lisa K Stamp ₅ , Nicola Dalbeth ₆ , Changgui Li ₁ , Tony R Merriman ₇

Affiliation

A. Ji, PhD, Research Fellow, C. Li, PhD, Professor, Shandong Provincial Key Laboratory of Metabolic Diseases, the Affiliated Hospital of Qingdao University, Qingdao, China.
A. Shaukat, MSc, Doctoral Student, M. Bixley, MSc, Assistant Research Fellow, M. Cadzow, PhD, Research Fellow, R.K. Topless, BSc, Assistant Research Fellow, T.J. Major, PhD, Research Fellow, A. Phipps-Green, MSc, Assistant Research Fellow, M.E. Merriman, BSc, Research Assistant, Department of Biochemistry, University of Otago, Dunedin, New Zealand.
R. Takei, MSc, Scientist, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA.
J. Harré Hindmarsh, PhD, Research Coordinator, Ngāti Porou Hauora Charitable Trust, Te Puia Springs, Tairāwhiti East Coast, New Zealand.
L.K. Stamp, PhD, Professor, Department of Medicine, University of Otago, Christchurch, New Zealand.
N. Dalbeth, MD, Professor, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
T.R. Merriman, BSc, Research Assistant, Shandong Provincial Key Laboratory of Metabolic Diseases, the Affiliated Hospital of Qingdao University, Qingdao, China, Department of Biochemistry, University of Otago, Dunedin, New Zealand, and Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA. A. Ji and A. Shaukat contributed equally to this work.

The Māori and Pacific (Polynesian) population of Aotearoa New Zealand (NZ) has a high prevalence of gout. Our aim was to identify potentially functional missense genetic variants in candidate inflammatory genes amplified in frequency that may underlie the increased prevalence of gout in Polynesian populations.

中文翻译：

Aotearoa 新西兰毛利人和太平洋地区特定人群痛风风险变异：CLNK 是 SLC2A9 基因座上的一个单独的风险基因。

新西兰 Aotearoa (NZ) 的毛利人和太平洋（波利尼西亚人）人口痛风患病率很高。我们的目标是确定频率放大的候选炎症基因中潜在的功能性错义遗传变异，这可能是波利尼西亚人群痛风患病率增加的基础。

更新日期：2021-07-05

点击分享查看原文

点击收藏

阅读更多本刊最新论文