Plasticised poly(lactic acid) (PLA)-based antimicrobial films were successfully produced via solvent-casting method. For this purpose, PLA copolymer-bearing quaternary ammonium salt in rate of 5 mol% was successfully fabricated through a two-step reaction procedure, i.e. combination of ring-opening copolymerization and copper(I)-catalysed azide–alkyne cycloaddition click reactions. The synthesized polymer was blended at three different amounts (5, 20 and 30% w/w) with commercial PLA which was plasticized with PEG-1000. After the blending process, antimicrobial activity of all the composite films was investigated against Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria via contact-active method. It was determined that the films blended with polymer containing quaternary ammonium salt on its backbone had a highly effective antimicrobial activity against both bacteria, even at the lowest blending rate. Besides, the thermo-mechanical behaviours of obtained films were analysed. Thermal property of films was not changed significantly after blending process of antimicrobial polymer. As a result, it can be said that the film which contains antimicrobial polymer at the lowest amount provides the purpose of this work with the highly effective antimicrobial activity and better mechanical properties compared to other films.

通过溶剂浇铸方法成功生产了增塑聚乳酸 (PLA) 基抗菌薄膜。为此，通过两步反应程序，即开环共聚和铜（I）催化的叠氮化物-炔环加成点击反应的组合，成功地制备了含 5 mol% PLA 共聚物的季铵盐。合成的聚合物以三种不同的量（5%、20% 和 30% w/w）与用 PEG-1000 增塑的商业 PLA 共混。混合过程后，研究了所有复合膜对革兰氏阳性（金黄色葡萄球菌）和革兰氏阴性（大肠杆菌）的抗菌活性) 细菌通过接触活性方法。已经确定，即使在最低混合速率下，与在其骨架上含有季铵盐的聚合物共混的薄膜对这两种细菌也具有高效的抗菌活性。此外，还分析了所得薄膜的热机械行为。抗微生物聚合物共混后薄膜的热性能没有显着变化。因此，可以说，与其他薄膜相比，含有最低量抗菌聚合物的薄膜为这项工作提供了高效的抗菌活性和更好的机械性能。