Macrophages are the dominant immune cell types in the adipose tissue, the liver or the aortic wall and they were originally believed to mainly derived from monocytes to fuel tissue inflammation in cardiometabolic diseases. However, over the last decade the identification of tissue resident macrophages (trMacs) from embryonic origin in these metabolic tissues has provided a breakthrough in the field forcing to better comprehend macrophage diversity during pathological states. Infiltrated monocyte-derived macrophages (moMacs), similar to trMacs, adapt to the local metabolic environment that eventually shapes their functions. In this review, we will summarize the emerging versatility of macrophages in cardiometabolic diseases with a focus in the control of adipose tissue, liver and large vessels homeostasis.

巨噬细胞是脂肪组织、肝脏或主动脉壁中的主要免疫细胞类型，最初认为它们主要来源于单核细胞，以促进心脏代谢疾病中的组织炎症。然而，在过去十年中，在这些代谢组织中从胚胎起源中鉴定出组织驻留巨噬细胞 (trMac) 为该领域提供了突破，从而迫使人们更好地理解病理状态下的巨噬细胞多样性。浸润的单核细胞衍生的巨噬细胞 (moMacs)，类似于 trMacs，适应最终形成其功能的局部代谢环境。在这篇综述中，我们将总结巨噬细胞在心脏代谢疾病中出现的多功能性，重点是控制脂肪组织、肝脏和大血管的稳态。