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A new technique to analyse threshold-intensities based on time dependent change-points in the ratio of minute ventilation and end-tidal partial pressure of carbon-dioxide production
Respiratory Physiology & Neurobiology ( IF 1.9 ) Pub Date : 2021-07-03 , DOI: 10.1016/j.resp.2021.103735
Ozgur Ozkaya 1 , Gorkem A Balci 1 , Hakan As 2 , Engin Yildiztepe 3
Affiliation  

The aim of this study was to test the utility and effectiveness of an alternative computational approach to threshold-intensities based on time dependent change-points in minute ventilation divided by end-tidal partial pressure of CO2 (VE/PETCO2) to reveal whether respiratory compensation point (RCP) is a third ventilatory threshold, or not. Ten recreationally active young adults and ten well-trained athletes volunteered to take part in this study. Following incremental ramp tests, gas exchange threshold (GET) and respiratory compensation point (RCP) were respectively evaluated by the slopes of VCO2-VO2 and VE-VCO2 using the Innocor system automatically. Respiratory threshold (RT) was analysed based on time dependent change-points in the VE/PETCO2 using binary segmentation algorithm. Additionally, those intersections were analysed independently by two experienced investigators using a visual identification technique in a double-blind design. According to the results, in the recreationally active group, there were the first (GET1) and the second (GET2) gas exchange thresholds which were identical with the RT1 (139 W; 1.9 L⋅min−1 of VO2; 1.73 L⋅min−1 of VCO2; 49.9 L⋅min−1 of VE versus 139 W; 1.88 L⋅min−1; 1.7 L⋅min−1; 49 L⋅min−1, respectively) and RT2 (186 W; 2.39 L⋅min−1 of VO2; 2.44 L⋅min−1 of VCO2; 66 L⋅min−1 of VE versus 187 W; 2.41 L⋅min−1; 2.49 L⋅min−1; 65.7 L⋅min−1, respectively). However, there were three threshold intensities which were determined by GET1, GET2, and RCP in well-trained athletes. Additionally, RT1, RT2, and RT3 were determined as valid surrogates of the GET1 (194 W; 2.56 L⋅min−1 of VO2; 1.99 L⋅min−1 of VCO2; 57.5 L⋅min−1 of VE versus 192 W; 2.61 L⋅min−1; 1.99 Lmin−1; 57.7 L⋅min−1, respectively), GET2 (267 W; 3.6 L⋅min−1 of VO2; 3.29 L⋅min−1 of VCO2; 94.5 L⋅min−1 of VE versus 266 W; 3.58 L⋅min−1; 3.26 L⋅min−1; 93.4 L⋅min−1, respectively), and RCP (324 W; 4.05 L⋅min−1 of VO2; 4.13 L⋅min−1 of VCO2; 124 L⋅min−1 of VE versus 322 W; 4.02 L⋅min−1; 4.07 L⋅min−1; 122 L⋅min−1, respectively) in well-trained athletes. There were high levels of agreements between the power outputs determined by traditional techniques and newly proposed change-points in RT. All markers were strongly correlated (p < 0.001). It was shown that RT technique can provide an accurate threshold determination. Furthermore, the RCP was observed as a third threshold-intensity for well-trained athletes but not for recreationally active young adults.



中文翻译:

基于每分钟通气量与呼气末二氧化碳分压比值随时间变化点分析阈值强度的新技术

本研究的目的是测试阈值强度的替代计算方法的实用性和有效性,该方法基于每分钟通气量的时间依赖性变化点除以 CO 2的呼气末分压(V E /P ET CO 2 )揭示呼吸补偿点 (RCP) 是否是第三通气阈值。十名休闲活跃的年轻人和十名训练有素的运动员自愿参加这项研究。在增量斜坡测试之后,分别通过 VCO 2 -VO 2和 V E -VCO 2的斜率评估气体交换阈值(GET)和呼吸补偿点(RCP)自动使用 Innocor 系统。呼吸阈值 (RT) 基于 V E /P ET CO 2中的时间相关变化点使用二元分割算法进行分析。此外,两名经验丰富的研究人员在双盲设计中使用视觉识别技术独立分析了这些交叉点。结果显示,在休闲活动组中,第一(GET 1)和第二(GET 2)气体交换阈值与RT 1相同(139 W; VO 2 1.9 L·min -1;VCO 2 1.73 L⋅min -1;49.9 L⋅min -1V E与 139 W;1.88 L⋅min -1 ; 1.7 L·min -1 ; 分别为49 L⋅min -1)和 RT 2(186 W;VO 2的 2.39 L⋅min -1 ; VCO 2的2.44 L⋅min -1 ; V E的66 L⋅min -1与 187 W 相比;2.41 L⋅min -1;2.49 L⋅min -1;65.7 L⋅min -1)。然而,在训练有素的运动员中,存在由 GET 1、 GET 2和 RCP 确定的三个阈值强度。此外,RT 1、RT 2和 RT3被确定为 GET 1的有效替代物(194 W; VO 2的2.56 L·min -1 ; VCO 2的1.99 L·min -1 ; V E的57.5 L·min -1与 192 W;2.61 L· min -1 ; 1.99 Lmin -1 ; 57.7 L⋅min -1 ),GET 2 (267 W; 3.6 L⋅min -1 of VO 2 ; 3.29 L⋅min -1 of VCO 2 ; 94.5 L⋅min - 1 V E与 266 W;3.58 L⋅min -1;3.26 L⋅min -1;93.4 L⋅min -1,分别)和RCP(324 W; VO 2的4.05 L·min -1 ; VCO 2的4.13 L·min -1 ; V E的124 L·min -1对比 322 W;4.02 L·min -1; 4.07 L⋅min -1 ; 122 L⋅min -1,分别)在训练有素的运动员。传统技术确定的功率输出与 RT 中新提出的变化点之间存在高度一致。所有标志物都高度相关(p < 0.001)。结果表明,RT技术可以提供准确的阈值确定。此外,RCP 被观察为训练有素的运动员的第三阈值强度,但不适用于休闲活动的年轻人。

更新日期:2021-07-20
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