Purpose

The National Institutes of Health announced the Healthy Brain and Child Development (HBCD) study to further understanding of infant brain development. This study examined perceptions and knowledge about research among the demographic groups to be studied in HBCD.

Method

1164 participants (n = 548 pregnant people and 616 mothers of infants < 12 months) completed anonymous, on-line surveys. Domains included research literacy, MRI knowledge, and attitudes about research incentives and biospecimen collection. Logistic regression was used to examine factors related to outcome variables.

Results

Knowledge of MRI safety was low and research literacy was high across participants. Likelihood of participation given various incentives differed between participants. Those with lower education were less likely to rate any items as increasing likelihood of participation. Substance use during pregnancy improved the model fit only for items about alternate visit structures (home and telephone visits) and confidentiality.

Conclusion

Overall results support the feasibility of infant imaging studies, such as HBCD with respondents having high research literacy and interest in learning about their baby’s development. Educating potential participants about MRI safety and providing flexible incentives for participation will improve the success of infant MRI studies.

中文翻译：

---

与家长参与婴儿 MRI 研究的看法相关的因素为健康大脑和儿童发育 (HBCD) 研究的设计提供指导

 目的

美国国立卫生研究院宣布了健康大脑和儿童发育（HBCD）研究，以进一步了解婴儿大脑发育。本研究调查了六溴环十二烷研究对象人口群体对研究的看法和知识。

 方法

1164 名参与者（n = 548 名孕妇和 616 名 < 12 个月婴儿的母亲）完成了匿名在线调查。领域包括研究素养、MRI 知识以及对研究激励和生物样本收集的态度。逻辑回归用于检查与结果变量相关的因素。

 结果

参与者对 MRI 安全性的了解较低，但研究素养较高。考虑到各种激励因素，参与者之间的参与可能性有所不同。受教育程度较低的人不太可能将任何项目评为参与可能性增加的项目。怀孕期间的物质使用改善了模型仅适用于有关交替访问结构（家庭和电话访问）和保密性的项目。

 结论

总体结果支持婴儿成像研究（例如六溴环十二烷）的可行性，受访者具有较高的研究素养和对了解婴儿发育的兴趣。对潜在参与者进行 MRI 安全教育并为参与提供灵活的激励措施将提高婴儿 MRI 研究的成功率。