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Ambulatory assessment for precision psychiatry: Foundations, current developments and future avenues
Experimental Neurology ( IF 5.3 ) Pub Date : 2021-07-03 , DOI: 10.1016/j.expneurol.2021.113807
Markus Reichert 1 , Gabriela Gan 2 , Malika Renz 2 , Urs Braun 2 , Sarah Brüßler 3 , Irina Timm 3 , Ren Ma 2 , Oksana Berhe 2 , Anastasia Benedyk 2 , Alexander Moldavski 2 , Janina I Schweiger 2 , Oliver Hennig 2 , Francesca Zidda 2 , Christine Heim 4 , Tobias Banaschewski 5 , Heike Tost 2 , Ulrich W Ebner-Priemer 6 , Andreas Meyer-Lindenberg 2
Affiliation  

Precision psychiatry stands to benefit from the latest digital technologies for assessment and analyses to tailor treatment towards individuals. Insights into dynamic psychological processes as they unfold in humans' everyday life can critically add value in understanding symptomatology and environmental stressors to provide individualized treatment where and when needed.

Towards this goal, ambulatory assessment encompasses methodological approaches to investigate behavioral, physiological, and biological processes in humans' everyday life. It combines repeated assessments of symptomatology over time, e.g., via Ecological Momentary Assessment (e.g., smartphone-diaries), with monitoring of physical behavior, environmental characteristics (such as geolocations, social interactions) and physiological function via sensors, e.g., mobile accelerometers, global-positioning-systems, and electrocardiography.

In this review, we expand on promises of ambulatory assessment in the investigation of mental states (e.g., real-life, dynamical and contextual perspective), on chances for precision psychiatry such as the prediction of courses of psychiatric disorders, detection of tipping points and critical windows of relapse, and treatment effects as exemplified by ongoing projects, and on future avenues of how ambulatory interventions can benefit personalized care for psychiatric patients (e.g., through real-time feedback in everyday life). Ambulatory assessment is a key contributor to precision psychiatry, opening up promising avenues in research, diagnoses, prevention and treatment.



中文翻译:

精准精神病学的动态评估:基础、当前发展和未来途径

精准精神病学将受益于最新的数字技术进行评估和分析,从而为个人量身定制治疗方案。深入了解在人类日常生活中展开的动态心理过程,可以极大地增加理解症状学和环境压力源的价值,从而在需要的时间和地点提供个性化的治疗。

为实现这一目标,动态评估包括研究人类日常生活中的行为、生理和生物过程的方法论方法。它结合了随着时间的推移对症状的重复评估,例如,通过生态瞬时评估(例如,智能手机日记),以及通过传感器(例如,移动加速度计)监测身体行为、环境特征(例如地理位置、社交互动)和生理功能,全球定位系统和心电图。

在这篇综述中,我们扩展了对精神状态调查中动态评估的承诺(例如,现实生活、动态和背景视角)、精确精神病学的机会,例如预测精神疾病的病程、检测临界点和复发的关键窗口和正在进行的项目所体现的治疗效果,以及门诊干预如何使精神病患者的个性化护理受益的未来途径(例如,通过日常生活中的实时反馈)。动态评估是精确精神病学的关键贡献者,为研究、诊断、预防和治疗开辟了有前途的途径。

更新日期:2021-08-09
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