Dissecting human trophoblast cell transcriptional heterogeneity in preeclampsia using single-cell RNA sequencing,Molecular Genetics & Genomic Medicine

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Dissecting human trophoblast cell transcriptional heterogeneity in preeclampsia using single-cell RNA sequencing
Molecular Genetics & Genomic Medicine ( IF 1.5 ) Pub Date : 2021-07-02 , DOI: 10.1002/mgg3.1730
Tao Zhang ₁ , Qianqian Bian ₂ , Yanchun Chen ₃ , Xiaolin Wang ₄ , Shaowei Yu ₅ , Shunhua Liu ₅ , Ping Ji ₅ , Ling Li ₅ , Mandakini Shrestha ₆ , Shujun Dong ₅ , Rong Guo ₇ , Hong Zhang ₁

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PE is a pregnancy-specific syndrome that affects 3%–5% of pregnant women. It often presents as new-onset hypertension and proteinuria during the third trimester. PE progresses rapidly and may lead to serious complications, including the death of both mother and fetus. In low-income countries, PE is one of the main causes of maternal and child mortality. While the cause of PE is still debated, clinical and pathological studies suggest that the placenta plays an important role in the pathogenesis of PE.

中文翻译：

使用单细胞 RNA 测序剖析先兆子痫中的人滋养层细胞转录异质性

PE 是一种妊娠特异性综合征，影响 3%–5% 的孕妇。它通常在妊娠晚期表现为新发高血压和蛋白尿。PE进展迅速，并可能导致严重的并发症，包括母亲和胎儿的死亡。在低收入国家，PE是孕产妇和儿童死亡的主要原因之一。虽然 PE 的病因仍有争议，但临床和病理学研究表明，胎盘在 PE 的发病机制中起重要作用。

更新日期：2021-08-30

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