Solute Transport Dependence on 3D Geometry of Hydrogel Networks,Macromolecular Chemistry and Physics

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Solute Transport Dependence on 3D Geometry of Hydrogel Networks
Macromolecular Chemistry and Physics ( IF 2.5 ) Pub Date : 2021-07-02 , DOI: 10.1002/macp.202100138
Nathan R Richbourg ₁ , Akhila Ravikumar ₁ , Nicholas A Peppas _{1,

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Affiliation

Hydrogels are used in drug delivery applications, chromatography, and tissue engineering to control the rate of solute transport based on solute size and hydrogel-solute affinity. Ongoing modeling efforts to quantify the relationship between hydrogel properties, solute properties, and solute transport contribute toward an increasingly efficient hydrogel design process and provide fundamental insight into the mechanisms relating hydrogel structure and function. However, here previous conclusions regarding the use of mesh size in hydrogel transport models are clarified. 3D geometry and hydrogel network visualizations are used to show that mesh size and junction functionality both contribute to the mesh radius, which determines whether a solute can diffuse within a hydrogel. Using mesh radius instead of mesh size to model solute transport in hydrogels will correct junction functionality-dependent modeling errors, improving hydrogel design predictions and clarifying mechanisms of solute transport in hydrogels.

中文翻译：

溶质传输对水凝胶网络 3D 几何形状的依赖性

水凝胶用于药物输送应用、色谱法和组织工程，根据溶质大小和水凝胶-溶质亲和力来控制溶质转运速率。正在进行的量化水凝胶性质、溶质性质和溶质运输之间关系的建模工作有助于提高水凝胶设计过程的效率，并提供对水凝胶结构和功能相关机制的基本见解。然而，这里澄清了先前关于在水凝胶传输模型中使用网格尺寸的结论。3D 几何和水凝胶网络可视化用于显示网格尺寸和连接功能都对网格半径有影响，这决定了溶质是否可以在水凝胶内扩散。使用网格半径而不是网格尺寸来模拟水凝胶中的溶质传输将纠正与连接功能相关的建模错误，改进水凝胶设计预测并阐明水凝胶中溶质传输的机制。

更新日期：2021-08-20

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