Red blood cell hemolysis induced by ultrasound and alkyl derivatives of amphotericin B and levorin modified by the amine and carboxyl groups has been studied. A kinetic method has been developed for studying the physico-chemical characteristics of blood cells during ultrasound physiotherapy. It was shown that the interaction of ultrasound with biological systems is based on the cavitation effect. The effects of alkyl derivatives of amphotericin B and levorin on the physicochemical characteristics of red blood cells were examined. It is assumed that the change in the mechanical stability of red blood cells in the presence of polyenes is associated with alteration in microviscosity of the protein–lipid system of RBC membranes through the formation of ion channels. A correlation was found between the effects of polyenes on lipid and cell membranes.

已经研究了由超声和两性霉素 B 的烷基衍生物和由胺和羧基修饰的左旋素引起的红细胞溶血。已经开发了一种动力学方法来研究超声理疗过程中血细胞的理化特性。结果表明，超声波与生物系统的相互作用是基于空化效应。研究了两性霉素 B 和左旋肉碱的烷基衍生物对红细胞理化特性的影响。据推测，在多烯存在下，红细胞机械稳定性的变化与红细胞膜蛋白质-脂质系统通过离子通道形成的微粘度变化有关。发现多烯对脂质和细胞膜的影响之间存在相关性。