This study was conducted to investigate the antistress potential of resveratrol, a natural polyphenol, in models that reproduce the conditions of acute hypobaric hypoxia and acute alcohol intoxication. Acute alcohol intoxication and acute hypobaric hypoxia induced an increase in the intensity of lipid peroxidation in the membranes of liver mitochondria from mice. Activation of lipid peroxidation was accompanied by swelling and variations in the levels of fatty acids with C₁₈ and C_20–22 in the composition of the total lipid fraction of mitochondrial membranes. The index of the unsaturation of fatty acids with C₁₈ was decreased by 7.5% (from 1.69 ± 0.01 to 1.52 ± 0.01). Furthermore, the (20:3ω6+20:5ω3)/22:6ω3 index decreased from 0.23 ± 0.02 to 0.13 ± 0.01 for fatty acids under acute hypobaric hypoxia conditions, suggesting a decrease in eicosanoid metabolism. The administration of 2 × 10^–5 mol/kg of resveratrol in animals for 5 days prevented changes in fatty acid composition, inhibiting activation of lipid peroxidation and swelling of mitochondria, thereby affecting physiological parameters. Thus, the adaptogenic properties of resveratrol may be ascribed to the prevention of lipid peroxidation in mitochondrial membranes, which probably affects the functional state of these organelles, contributing to the maintenance of cellular energy metabolism under stress conditions.

本研究旨在研究白藜芦醇（一种天然多酚）在重现急性低压缺氧和急性酒精中毒条件的模型中的抗应激潜力。急性酒精中毒和急性低压缺氧导致小鼠肝线粒体膜脂质过氧化强度增加。脂质过氧化的激活伴随着线粒体膜总脂质部分组成中具有 C ₁₈和 C _20-22的脂肪酸水平的膨胀和变化。C ₁₈脂肪酸不饱和度指数下降了 7.5%（从 1.69 ± 0.01 到 1.52 ± 0.01）。此外，在急性低压缺氧条件下，脂肪酸的 (20:3ω6+20:5ω3)/22:6ω3 指数从 0.23 ± 0.02 降至 0.13 ± 0.01，表明类花生酸代谢减少。给动物服用 2 × 10 ^–5 mol/kg 白藜芦醇 5 天，可防止脂肪酸组成发生变化，抑制脂质过氧化激活和线粒体肿胀，从而影响生理参数。因此，白藜芦醇的适应性特性可能归因于防止线粒体膜中的脂质过氧化，这可能影响这些细胞器的功能状态，有助于在压力条件下维持细胞能量代谢。