Abstract

Leishmania (L.) amazonensis is one of the species responsible for the development of cutaneous leishmaniasis in South America. After entering the vertebrate host, L. (L.) amazonensis invades mainly neutrophils, macrophages, and dendritic cells. Studies have shown that gal-3 acts as a pattern recognition receptor. However, the role of this protein in the context of L. (L.) amazonensis infection remains unclear. Here, we investigated the impact of gal-3 expression on experimental infection by L. (L.) amazonensis. Our data showed that gal-3 plays a role in controlling parasite invasion, replication and the formation of endocytic vesicles. Moreover, mice with gal-3 deficiency showed an exacerbated inflammatory response. Taken together, our data shed light to a critical role of gal-3 in the host response to infection by L. (L.) amazonensis.

中文翻译：

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Galectin-3在亚马逊利什曼原虫（Leishmania）感染中起保护作用

摘要

亚马逊利什曼原虫 (L.) amazonensis是导致南美洲皮肤利什曼病发展的物种之一。进入脊椎动物宿主后，L. (L.) amazonensis主要侵入中性粒细胞、巨噬细胞和树突状细胞。研究表明，gal-3 充当模式识别受体。然而，这种蛋白质在L. (L.) amazonensis感染中的作用仍不清楚。在这里，我们研究了 gal-3 表达对L. (L.) amazonensis实验性感染的影响. 我们的数据表明，gal-3 在控制寄生虫入侵、复制和内吞囊泡的形成中发挥作用。此外，gal-3 缺乏的小鼠表现出加剧的炎症反应。总之，我们的数据揭示了 gal-3 在宿主对L. (L.) amazonensis感染的反应中的关键作用。