Quassinoids with Inhibitory Activities against Plant Fungal Pathogens from Picrasma javanica,Journal of Natural Products

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Quassinoids with Inhibitory Activities against Plant Fungal Pathogens from Picrasma javanica
Journal of Natural Products ( IF 3.3 ) Pub Date : 2021-07-01 , DOI: 10.1021/acs.jnatprod.1c00096
Jian-Jun Chen ₁ , Wei Bai ₁ , Yu-Bo Lu ₁ , Zi-Yun Feng ₁ , Kun Gao ₁ , Jian-Min Yue _{1,

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Affiliation

A bioactivity-guided study on the leaves of Picrasma javanica led to the isolation of 19 quassinoids, including 13 new compounds. The structures of the new compounds were elucidated by a combination of spectroscopic data analysis, X-ray crystallography studies, and electronic circular dichroism (ECD) data interpretation. Compounds 1–7 are rare examples of quassinoids with a keto carbonyl group at C-12. The biological activities of 11 of the more abundant isolates were evaluated against five phytopathogenic fungi in vitro, and several of them including 6 and 15 showed moderate inhibitory effects that were comparative to those of the positive control, carbendazim. In addition, the preliminary structure–activity relationships (SARs) of these quassinoids were also investigated.

中文翻译：

对爪哇野草的植物真菌病原体具有抑制活性的类拟甙元

一项对爪哇草叶子的生物活性指导研究导致分离出 19 种类黄酮，包括 13 种新化合物。通过光谱数据分析、X 射线晶体学研究和电子圆二色性 (ECD) 数据解释的组合阐明了新化合物的结构。化合物1 – 7是在 C-12 处具有酮羰基的类类化合物的罕见例子。在体外评估了 11 种更丰富的分离株对 5 种植物病原真菌的生物活性，其中包括6 种和15 种显示出与阳性对照多菌灵相比的中等抑制作用。此外，还研究了这些 quassinoids 的初步构效关系 (SAR)。

更新日期：2021-08-27

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