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Quassinoids with Inhibitory Activities against Plant Fungal Pathogens from Picrasma javanica
Journal of Natural Products ( IF 3.3 ) Pub Date : 2021-07-01 , DOI: 10.1021/acs.jnatprod.1c00096
Jian-Jun Chen 1 , Wei Bai 1 , Yu-Bo Lu 1 , Zi-Yun Feng 1 , Kun Gao 1 , Jian-Min Yue 1, 2, 3
Affiliation  

A bioactivity-guided study on the leaves of Picrasma javanica led to the isolation of 19 quassinoids, including 13 new compounds. The structures of the new compounds were elucidated by a combination of spectroscopic data analysis, X-ray crystallography studies, and electronic circular dichroism (ECD) data interpretation. Compounds 17 are rare examples of quassinoids with a keto carbonyl group at C-12. The biological activities of 11 of the more abundant isolates were evaluated against five phytopathogenic fungi in vitro, and several of them including 6 and 15 showed moderate inhibitory effects that were comparative to those of the positive control, carbendazim. In addition, the preliminary structure–activity relationships (SARs) of these quassinoids were also investigated.

中文翻译:

对爪哇野草的植物真菌病原体具有抑制活性的类拟甙元

一项对爪哇草叶子的生物活性指导研究导致分离出 19 种类黄酮,包括 13 种新化合物。通过光谱数据分析、X 射线晶体学研究和电子圆二色性 (ECD) 数据解释的组合阐明了新化合物的结构。化合物17是在 C-12 处具有酮羰基的类类化合物的罕见例子。在体外评估了 11 种更丰富的分离株对 5 种植物病原真菌的生物活性,其中包括6 种15 种显示出与阳性对照多菌灵相比的中等抑制作用。此外,还研究了这些 quassinoids 的初步构效关系 (SAR)。
更新日期:2021-08-27
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