In eukaryotic cells, mRNA molecules are coated with numerous RNA-binding proteins and so exist in ribonucleoproteins (mRNPs). The proteins associated with the mRNA regulate the fate of mRNA, including its localization, translation and decay. Before activation of translation, the mRNA does not display any template functions—it is masked. The coordinated activity of certain RNA-binding proteins determines the future fate of each mRNA individually. In embryo development, the temporal and spatial regulation of translation can cause a situation when the mRNA and the encoded protein are localized in different compartments and so the differentiation of the cells can be determined. The fundamentals of regulation of the mRNAs fate and functioning in nerves are similar to those already described for oo- and embryogenesis. Disorders in the mRNA masking and demasking result in the emergence of various diseases, in particular cancers and neuro-degenerative diseases.

中文翻译：

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mRNPs：发展中的结构和作用

在真核细胞中，mRNA 分子被大量的 RNA 结合蛋白包裹，因此存在于核糖核蛋白 (mRNP) 中。与 mRNA 相关的蛋白质调节 mRNA 的命运，包括其定位、翻译和衰变。在翻译激活之前，mRNA 不显示任何模板功能——它被掩盖了。某些 RNA 结合蛋白的协同活动分别决定了每个 mRNA 的未来命运。在胚胎发育中，翻译的时间和空间调节会导致 mRNA 和编码的蛋白质位于不同的隔室中，因此可以确定细胞的分化。mRNA 在神经中的命运和功能调节的基本原理与已经描述的 oo- 和胚胎发生的基本原理相似。