ABSTRACT

Objective

Alcohol abuse causes several neurological disorders. Resveratrol is a natural polyphenol that occurs as a phytoalexin. In different studies, it has been investigated that resveratrol has positive effects on various mechanisms that are important in drug addiction or substance use disorder. The objective of the present study was to examine the effect of resveratrol on alcohol-induced conditioned place preference (CPP) in mice.

Methods

CPP was induced by intraperitoneal (i.p.) administration of ethanol (2 g/kg) in an 8-day conditioning program. The influence of reference drug, acamprosate and resveratrol on the rewarding properties of ethanol was tested in mice given treatment of acamprosate (300 mg/kg, i.p.) and resveratrol (25, 50, and 75 mg/kg, i.p.) 30 minutes prior to ethanol administration. Once established, CPP was extinguished by repeated testing, through which conditioned mice were administered acamprosate, various doses of resveratrol or saline daily. Subsequently, the potency of acamprosate and resveratrol in preventing reinstatement of CPP provoked by priming with low-dose ethanol (0.4 g/kg, i.p.) was also evaluated.

Results

The present findings confirm that resveratrol impairs acquisition, reinstatement and precipitates the extinction of preference for alcohol-induced CPP. Resveratrol presented a similar effect in the CPP phases to the acamprosate.

Conclusions

The effect of resveratrol on ethanol-induced CPP in mice demonstrated for the first time. As a conclusion, these findings may shed light on the fact that resveratrol can be utilized as an agent which is potentially beneficial to prevent the various harmful effects of ethanol, however, more research is needed to completely elucidate this attribute.

中文翻译：

---

白藜芦醇会损害小鼠酒精诱导的位置偏好的获得、恢复和消除

摘要

客观的

酗酒会导致多种神经系统疾病。白藜芦醇是一种天然多酚，以植物抗毒素的形式出现。在不同的研究中，研究表明白藜芦醇对药物成瘾或物质使用障碍中重要的各种机制具有积极作用。本研究的目的是检查白藜芦醇对小鼠酒精诱导的条件性位置偏好 (CPP) 的影响。

方法

在为期 8 天的调理程序中，通过腹膜内 (ip) 给予乙醇 (2 g/kg) 来诱导 CPP。参考药物、阿坎酸和白藜芦醇对乙醇奖励特性的影响在小鼠中进行了测试，这些小鼠在 30 分钟前给予阿坎酸（300 mg/kg，ip）和白藜芦醇（25、50 和 75 mg/kg，ip）治疗。乙醇给药。一旦建立，CPP 通过重复测试被熄灭，通过该测试，每天给条件小鼠服用阿坎酸、各种剂量的白藜芦醇或盐水。随后，还评估了阿坎酸和白藜芦醇在预防由低剂量乙醇（0.4 g/kg，ip）引发的 CPP 恢复中的效力。

结果

目前的研究结果证实，白藜芦醇会损害获得、恢复并促使对酒精诱导的 CPP 的偏好消失。白藜芦醇在 CPP 阶段表现出与阿坎酸相似的效果。

结论

白藜芦醇对小鼠乙醇诱导的CPP的影响首次得到证实。作为结论，这些发现可能揭示了白藜芦醇可用作预防乙醇各种有害影响的潜在有益剂这一事实，然而，需要更多的研究来完全阐明这一属性。