T cell asymmetry upon specific cell–cell interactions during mammalian immunological synapse (IS) contacts requires mammalian target of rapamycin complex (mTORC) activation and chaperones, such as the eukaryotic chaperonin containing TCP1 (CCT) for protein synthesis and folding. This mechanism can control cytoskeleton dynamics, and regulate mitochondrial fate, respiration, and metabolic rates, ultimately underlying cell reprogramming events that are relevant for CD4⁺ T cell functional outcomes.

中文翻译：

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T 细胞不对称和代谢串扰可以微调免疫突触

在哺乳动物免疫突触 (IS) 接触期间，特定细胞间相互作用导致 T 细胞不对称需要哺乳动物雷帕霉素复合物 (mTORC) 激活和伴侣蛋白，例如用于蛋白质合成和折叠的含有 TCP1 的真核伴侣蛋白 (CCT)。这种机制可以控制细胞骨架动力学，调节线粒体命运、呼吸和代谢率，最终导致与 CD4 ⁺ T 细胞功能结果相关的细胞重编程事件。