Several recent preclinical studies have demonstrated that simultaneously blocking exogenous and endogenous sources of serine in malignant cells mediates superior anticancer effects as compared with limiting either source alone. Here, we critically summarize key developments in targeting serine to treat cancer and discuss persisting challenges for implementing such a therapeutic approach in patients.

中文翻译：

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在癌症中靶向丝氨酸：两个比一个好？

最近的几项临床前研究表明，与单独限制任一来源相比，同时阻断恶性细胞中外源性和内源性丝氨酸来源可介导更好的抗癌作用。在这里，我们批判性地总结了靶向丝氨酸治疗癌症的关键进展，并讨论了在患者中实施这种治疗方法的持续挑战。