To identify priorities for administrative, epidemiologic and diagnostic research in sepsis. As a follow-up to a previous consensus statement about sepsis research, members of the Surviving Sepsis Campaign Research Committee, representing the European Society of Intensive Care Medicine and the Society of Critical Care Medicine addressed six questions regarding care delivery, epidemiology, organ dysfunction, screening, identification of septic shock, and information that can predict outcomes in sepsis. Six questions from the Scoring/Identification and Administration sections of the original Research Priorities publication were explored in greater detail to better examine the knowledge gaps and rationales for questions that were previously identified through a consensus process. The document provides a framework for priorities in research to address the following questions: (1) What is the optimal model of delivering sepsis care?; (2) What is the epidemiology of sepsis susceptibility and response to treatment?; (3) What information identifies organ dysfunction?; (4) How can we screen for sepsis in various settings?; (5) How do we identify septic shock?; and (6) What in-hospital clinical information is associated with important outcomes in patients with sepsis? There is substantial knowledge of sepsis epidemiology and ways to identify and treat sepsis patients, but many gaps remain. Areas of uncertainty identified in this manuscript can help prioritize initiatives to improve an understanding of individual patient and demographic heterogeneity with sepsis and septic shock, biomarkers and accurate patient identification, organ dysfunction, and ways to improve sepsis care.

中文翻译：

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脓毒症生存运动：脓毒症管理、流行病学、评分和识别的研究重点

确定脓毒症行政、流行病学和诊断研究的优先事项。作为先前关于脓毒症研究的共识声明的后续行动，代表欧洲重症监护医学学会和重症监护医学学会的存活脓毒症运动研究委员会成员解决了关于护理提供、流行病学、器官功能障碍、筛查、感染性休克的识别以及可以预测败血症结果的信息。更详细地探讨了原始研究优先级出版物的评分/识别和管理部分的六个问题，以更好地检查先前通过共识过程确定的问题的知识差距和基本原理。该文件为研究优先事项提供了一个框架，以解决以下问题：(1) 提供脓毒症护理的最佳模式是什么？(2) 败血症易感性和治疗反应的流行病学是什么？(3) 哪些信息可以识别器官功能障碍？(4) 如何在各种环境下筛查败血症？(5) 如何鉴别感染性休克？(6) 哪些院内临床信息与脓毒症患者的重要结局相关？人们对脓毒症流行病学以及识别和治疗脓毒症患者的方法有大量了解，但仍有许多差距。本手稿中确定的不确定领域可以帮助确定优先事项，以提高对脓毒症和脓毒症休克、生物标志物和准确患者识别的个体患者和人口统计学异质性的理解，