The use of probiotics has been applied for a variety of fields (e.g., immune system, mental health, and heart). In this study, the feasibility of lysates from L. rhamnosus IDCC 3201 for cosmetic ingredients was evaluated. More specifically, enhanced ceramides production in human epidermal keratinocytes by the lysates and its proposed machanism were investigated through in vitro and genome analysis. In results, enhanced spingomyelinase activity and thereby increased ceramides production by the lysates from L. rhamnosus IDCC 3201 was observed. Furthermore, it was found that the existence of glucosylceramdase in L. rhamonsus IDCC 3201 was attributed to enhanced ceramides production. Finally, it was verified that the lysates from L. rhamonsus IDCC 3201 was regarded as safe for its use as cosmetic materials. Thus, these findings have significant implications that might lead to the development of functional and safe cosmetic products from probiotics.

中文翻译：

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鼠李糖乳杆菌IDCC 3201增强神经酰胺的产生及其提出的机制

益生菌的使用已应用于多个领域（例如，免疫系统、心理健康和心脏）。在本研究中，评估了鼠李糖乳杆菌 IDCC 3201 裂解物用于化妆品成分的可行性。更具体地说，通过体外和基因组分析研究了裂解物在人表皮角质形成细胞中增强神经酰胺的产生及其提出的机制。结果，观察到增强的脊髓髓鞘酶活​​性，从而增加了鼠李糖乳杆菌 IDCC 3201 裂解物产生的神经酰胺。此外，发现鼠李糖苷酸 IDCC 3201 中葡糖神经酰胺酶的存在归因于神经酰胺产量的增加。最后，证实来自鼠李糖乳杆菌 IDCC 3201 的裂解物被认为可安全用作化妆品材料。因此，