Resting state alpha power asymmetry in frontal and temporal regions has been reported in various clinical populations, possibly indicating deficits in prefrontal control. In panic disorder (PD), results regarding alpha asymmetric activity to date have been mixed. This study compared 55 PD patients and 42 healthy controls (HC) with regards to resting state alpha power asymmetry. Our results show more right-than-left fronto-lateral alpha power in PD, whereas at other sites and in HC no significant differences were detected. These results support the notion of altered neurobiological processes in PD that possibly represent a vulnerability to the experience of panic attacks. Further studies are needed to clarify potential causal implications of this finding in the genesis of PD, as well as to specify the functional significance of fronto-lateral alpha power asymmetry in PD.

已经在各种临床人群中报告了额叶和颞区的静息状态 α 功率不对称，这可能表明前额叶控制存在缺陷。在恐慌症 (PD) 中，迄今为止有关 alpha 不对称活动的结果喜忧参半。本研究比较了 55 名 PD 患者和 42 名健康对照 (HC) 的静息状态 α 功率不对称性。我们的结果显示 PD 中右额外侧 α 功率比左额多，而在其他部位和 HC 中未检测到显着差异。这些结果支持 PD 中神经生物学过程改变的概念，这可能代表了对惊恐发作经历的脆弱性。需要进一步的研究来阐明这一发现在 PD 发生中的潜在因果关系，