Assessing the mechanisms of action of natural molecules/extracts for phase-directed wound healing in hydrogel scaffolds,RSC Medicinal Chemistry

当前位置： X-MOL 学术 › RSC Med. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Assessing the mechanisms of action of natural molecules/extracts for phase-directed wound healing in hydrogel scaffolds
RSC Medicinal Chemistry ( IF 4.1 ) Pub Date : 2021-07-02 , DOI: 10.1039/d1md00100k
Itisha Chummun ₁ , Devesh Bekah ₁ , Nowsheen Goonoo ₁ , Archana Bhaw-Luximon ₁

Affiliation

Hydrogels are proving to be very versatile as wound healing devices. In addition to their capabilities of providing a moist cellular environment and adaptive mechanical properties mimicking the extracellular matrix, they allow the incorporation of small molecules, which have potential impacts on cellular behaviour, in their nanostructures. This strategy can allow for specific targeting of the different stages of wound healing namely hemostasis, inflammation, and proliferative and remodelling phases. The latter include interlinked processes such as angiogenesis, collagen synthesis, growth factor release, collagen maturation and re-epithelialization. In this review, we attempt to match the mechanisms of action of natural molecules/extracts to the different stages of wound healing so that they can be used in a novel approach of multiphase-directed tissue regeneration using loaded hydrogel scaffolds.

中文翻译：

评估天然分子/提取物在水凝胶支架中定向伤口愈合的作用机制

事实证明，水凝胶作为伤口愈合装置用途广泛。除了提供潮湿的细胞环境和模仿细胞外基质的适应性机械特性的能力之外，它们还允许在其纳米结构中掺入对细胞行为具有潜在影响的小分子。该策略可以具体针对伤口愈合的不同阶段，即止血、炎症、增殖和重塑阶段。后者包括相互关联的过程，例如血管生成、胶原合成、生长因子释放、胶原成熟和上皮再形成。在这篇综述中，我们尝试将天然分子/提取物的作用机制与伤口愈合的不同阶段相匹配，以便它们可以用于使用负载水凝胶支架的多相定向组织再生的新方法。

更新日期：2021-07-02

点击分享查看原文

点击收藏

阅读更多本刊最新论文